COVID-19 and multisystem inflammatory syndrome in children and adolescents

被引：552

作者：

Jiang, Li ^{[1
]}

Tang, Kun ^{[1
,3
]}

Levin, Mike ^{[4
]}

Irfan, Omar ^{[1
]}

Morris, Shaun K. ^{[1
,2
]}

Wilson, Karen ^{[5
]}

Klein, Jonathan D. ^{[6
]}

Bhutta, Zulfiqar A. ^{[1
,7
]}

机构：

[1] Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON M5G 1X8, Canada

[2] Hosp Sick Children, Div Infect Dis, Toronto, ON, Canada

[3] Tsinghua Univ, Vanke Sch Publ Hlth, Beijing, Peoples R China

[4] Imperial Coll London, Dept Infect Dis, London, England

[5] Mt Sinai Kravis Childrens Hosp, New York, NY USA

[6] Univ Illinois, Dept Pediat, Chicago, IL USA

[7] Aga Khan Univ, Inst Global Hlth & Dev, Karachi 74800, Pakistan

来源：

LANCET INFECTIOUS DISEASES | 2020年 / 20卷 / 11期

关键词：

ANTIBODY-DEPENDENT ENHANCEMENT; NEUTROPHIL EXTRACELLULAR TRAPS; CIRCULATING IMMUNE-COMPLEXES; GENOME-WIDE ASSOCIATION; DISEASE SHOCK SYNDROME; HUMAN CORONAVIRUS NL63; LONG-TERM MANAGEMENT; KAWASAKI-DISEASE; HEALTH-PROFESSIONALS; SARS CORONAVIRUS;

D O I：

10.1016/S1473-3099(20)30651-4

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

As severe acute respiratory syndrome coronavirus 2 continues to spread worldwide, there have been increasing reports from Europe, North America, Asia, and Latin America describing children and adolescents with COVID-19-associated multisystem inflammatory conditions. However, the association between multisystem inflammatory syndrome in children and COVID-19 is still unknown. We review the epidemiology, causes, clinical features, and current treatment protocols for multisystem inflammatory syndrome in children and adolescents associated with COVID-19. We also discuss the possible underlying pathophysiological mechanisms for COVID-19-induced inflammatory processes, which can lead to organ damage in paediatric patients who are severely ill. These insights provide evidence for the need to develop a clear case definition and treatment protocol for this new condition and also shed light on future therapeutic interventions and the potential for vaccine development.

引用

页码：E276 / E288

页数：13

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