Aging skin is functionally anaerobic: Importance of coenzyme Q10 for anti aging skin care

被引：62

作者：

Prahl, S. ^{[1
,2
]}

Kueper, T. ^{[1
]}

Biernoth, T. ^{[1
]}

Woehrmann, Y. ^{[1
]}

Muenster, A. ^{[1
]}

Fuerstenau, M. ^{[1
]}

Schmidt, M. ^{[1
]}

Schulze, C. ^{[1
]}

Wittern, K. -P. ^{[1
]}

Wenck, H. ^{[1
]}

Muhr, G. -M. ^{[1
]}

Blatt, T. ^{[1
]}

机构：

[1] Beiersdorf AG, R&D, D-20245 Hamburg, Germany

[2] Univ Hamburg, Dept Biochem & Mol Biol, Hamburg, Germany

来源：

BIOFACTORS | 2008年 / 32卷 / 1-4期

关键词：

CoQ(10); topical application; skin aging; keratinocytes; glucose; lactate; mitochondria;

D O I：

10.1002/biof.5520320129

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The functional loss of mitochondria represents an inherent part in modern theories trying to explain the cutaneous aging process. The present study shows significant age-dependent differences in mtitochondrial function of keratinocytes isolated from skin biopsies of young and old donors. Our data let us postulate that energy metabolism shifts to a predominantly non-mitochondrial pathway and is therefore functionally anaerobic with advancing age. CoQ(10) positively influences the age-affected cellular metabolism and enables to combat signs of aging starting at the cellular level. As a consequence topical application of CoQ(10) is beneficial for human skin as it rapidly improves mitochondrial function in skin in vivo.

引用

页码：245 / 255

页数：11

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