17 alpha-Dihydroequilenin increases hippocampal dendritic spine density of ovariectomized rats

被引：19
|
作者：
Washburn, SA
Lewis, CE
Johnson, JE
Voytko, ML
Shively, CA
机构：
[1] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT COMPARAT MED,WINSTON SALEM,NC 27157
[2] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT OBSTET & GYNECOL,WINSTON SALEM,NC 27157
[3] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT NEUROBIOL & ANAT,WINSTON SALEM,NC 27157
[4] DAVIDSON COLL,DEPT BIOL,DAVIDSON,NC 28036
来源：
BRAIN RESEARCH | 1997年 / 758卷 / 1-2期
关键词：
estrogen; memory; hormone replacement therapy; menopause; animal model;
D O I：
10.1016/S0006-8993(97)00303-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of estradiol and 17 alpha-dihydroequilenin on the apical dendrite spine density of pyramidal cells of the CA1 region of rat hippocampus were compared. 17 alpha-Dihydroequilenin was as effective as estradiol in increasing spine densities relative to controls. 17 alpha-Dihydroequilenin is not uterotrophic like estradiol but does have beneficial effects on the cardiovascular system, suggesting that it may be an effective single-agent hormone replacement therapy to treat menopausal symptoms and reduce chronic disease risk in menopausal women.
引用
收藏
页码：241 / 244
页数：4
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