Primary hepatic B-cell lymphoma of mucosa-associated lymphoid tissue

被引:0
|
作者
Kirk, CM [1 ]
Lewin, D [1 ]
Lazarchick, J [1 ]
机构
[1] Med Univ S Carolina, Dept Pathol & Lab Med, Charleston, SC 29414 USA
关键词
D O I
暂无
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Mucosa-associated lymphoid tissue (MALT) lymphomas are low-grade B-cell lymphomas that occur in a variety of extranodal sites but rarely as a primary hepatic lymphoma. We describe the histological findings, immunophenotype, and immunohistochemistry of one such lymphoma found incidentally in a 69-year-old woman. The lymphoid infiltrate invaded the liver in a serpiginous configuration with entrapment of nodules of normal liver. Reactive follicles were surrounded by intermediate-sized lymphoid cells with slightly irregular nuclei and pale cytoplasm. Only a few scattered lymphoepithelial lesions were identified since most of the bile ducts were destroyed. The immunophenotype determined by flow cytometry identified the lymphoid cells as being CD19, CD20 positive and exhibiting lambda light chain restriction. CD5, CD10, and CD23 were negative. Immunohistochemistry showed the neoplastic cells to be positive for CD20 (L-26) and bcl-2. The reactive follicles were negative for bcl-2. CD3 showed only a few scattered T cells. Cyclin D1 did not stain the neoplastic cells. Cytokeratin (AE1/AE3) highlighted the lymphoepithelial lesions and residual bile ducts. MALT lymphomas need to be recognized and distinguished from other B-cell lymphomas, particularly mantle cell lymphomas, because of the difference in behavior and treatment.
引用
收藏
页码:716 / 719
页数:4
相关论文
共 50 条
  • [41] Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder
    Chim, CS
    Liang, R
    Loong, F
    Chung, LP
    AMERICAN JOURNAL OF MEDICINE, 2002, 112 (06): : 505 - 507
  • [42] Primary prostatic lymphoma of mucosa-associated lymphoid tissue
    Tomikawa, S
    Okumura, H
    Yoshida, T
    Mochizuki, H
    Miwa, A
    Takayanagi, K
    Yoshino, T
    Ohtake, S
    Fujimura, M
    Nakamura, S
    Matsuda, T
    INTERNAL MEDICINE, 1998, 37 (07) : 628 - 630
  • [43] Primary Rectal Mucosa-Associated Lymphoid Tissue Lymphoma
    Zhou, Ting-Ting
    Wang, Xiao-Lu
    Liu, Wei
    JOURNAL OF GASTROINTESTINAL SURGERY, 2021, 25 (11) : 2997 - 2998
  • [44] Primary jejunal mucosa-associated lymphoid tissue lymphoma
    Chen, C. -T.
    Yen, H. -H.
    Wu, L.
    QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2013, 106 (02) : 195 - 196
  • [45] Primary renal lymphoma of mucosa-associated lymphoid tissue
    Tuzel, E
    Mungan, MU
    Yorukoglu, K
    Basakci, A
    Kirkali, Z
    UROLOGY, 2003, 61 (02)
  • [46] Primary mucosa-associated lymphoid tissue lymphoma of hypopharynx
    Firat, Yezdan
    Kizilay, Ahmet
    Sogutlu, Gokhan
    Mizrak, Bulent
    JOURNAL OF CRANIOFACIAL SURGERY, 2007, 18 (05) : 1189 - 1193
  • [47] Diffuse Large B-Cell Lymphoma Transformed from a Rectal Mucosa-Associated Lymphoid Tissue Lymphoma
    Kang, Sae Han
    Park, Jang Won
    Jung, Byung Wook
    Song, Jun Gyu
    Oh, Hyun Sik
    Park, Kwonoh
    EWHA MEDICAL JOURNAL, 2016, 39 (02): : 51 - 55
  • [49] MALIGNANT-LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID-TISSUE - A DISTINCTIVE TYPE OF B-CELL LYMPHOMA
    ISAACSON, P
    WRIGHT, DH
    CANCER, 1983, 52 (08) : 1410 - 1416
  • [50] Extranodal marginal zone B-cell lymphoma of pulmonary mucosa-associated lymphoid tissue (MALT lymphoma)
    Vergara-Uzcategui, Carlos
    Ruiz, Melizabeth
    AVANCES EN BIOMEDICINA, 2014, 3 (02): : 102 - 109