Primary hepatic B-cell lymphoma of mucosa-associated lymphoid tissue

被引:0
|
作者
Kirk, CM [1 ]
Lewin, D [1 ]
Lazarchick, J [1 ]
机构
[1] Med Univ S Carolina, Dept Pathol & Lab Med, Charleston, SC 29414 USA
关键词
D O I
暂无
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Mucosa-associated lymphoid tissue (MALT) lymphomas are low-grade B-cell lymphomas that occur in a variety of extranodal sites but rarely as a primary hepatic lymphoma. We describe the histological findings, immunophenotype, and immunohistochemistry of one such lymphoma found incidentally in a 69-year-old woman. The lymphoid infiltrate invaded the liver in a serpiginous configuration with entrapment of nodules of normal liver. Reactive follicles were surrounded by intermediate-sized lymphoid cells with slightly irregular nuclei and pale cytoplasm. Only a few scattered lymphoepithelial lesions were identified since most of the bile ducts were destroyed. The immunophenotype determined by flow cytometry identified the lymphoid cells as being CD19, CD20 positive and exhibiting lambda light chain restriction. CD5, CD10, and CD23 were negative. Immunohistochemistry showed the neoplastic cells to be positive for CD20 (L-26) and bcl-2. The reactive follicles were negative for bcl-2. CD3 showed only a few scattered T cells. Cyclin D1 did not stain the neoplastic cells. Cytokeratin (AE1/AE3) highlighted the lymphoepithelial lesions and residual bile ducts. MALT lymphomas need to be recognized and distinguished from other B-cell lymphomas, particularly mantle cell lymphomas, because of the difference in behavior and treatment.
引用
收藏
页码:716 / 719
页数:4
相关论文
共 50 条
  • [21] Extranodal marginal zone b-cell lymphoma of mucosa-associated lymphoid tissue of the gallbladder
    Ng, Sally K.
    Epari, Krishna
    Parsons, Sarah
    Wei, Andrew
    Banting, Simon W.
    SURGICAL PRACTICE, 2008, 12 (04) : 137 - 141
  • [22] The Diagnosis of Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue
    Huang, Na
    Li, Wei-Min
    CHEST, 2012, 141 (03) : 833 - 833
  • [23] GASTRIC B-CELL LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID-TISSUE IS A MULTIFOCAL DISEASE
    WOTHERSPOON, AC
    DOGLIONI, C
    ISAACSON, PG
    JOURNAL OF PATHOLOGY, 1990, 161 (04): : A345 - A345
  • [24] Primary hepatic marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type in a liver transplant patient with hepatitis B cirrhosis
    Nart, D
    Ertan, Y
    Yilmaz, F
    Yüce, G
    Zeytunlu, M
    Kilic, M
    TRANSPLANTATION PROCEEDINGS, 2005, 37 (10) : 4408 - 4412
  • [25] Primary hepatic extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue
    Choi, Soyeon
    Kim, Ji Hye
    Kim, Kyungbin
    Kim, Misung
    Choi, Hye Jeong
    Kim, Young Min
    Suh, Jae Hee
    Seo, Min Jung
    Cha, Hee Jeong
    JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, 2020, 54 (04) : 340 - 345
  • [26] Primary Hepatic Mucosa-Associated Lymphoid Tissue Lymphoma in a Patient with Primary Biliary Cholangitis
    Hamada, Kensuke
    Yamamoto, Shuji
    Seno, Hiroshi
    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2022, 20 (03) : E352 - E353
  • [27] Primary Hepatic Low-Grade B-Cell Lymphoma of the Mucosa-Associated Lymphoid Tissue Type: A Case Report and Review of the Literature
    Jun Murakami
    Noriyoshi Fukushima
    Hideki Ueno
    Takeshi Saito
    Takashi Watanabe
    Ryuji Tanosaki
    Yukio Kobayashi
    Yoshihiro Matsuno
    Kensei Tobinai
    International Journal of Hematology, 2002, 75 : 85 - 90
  • [28] Primary hepatic low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue type: A case report and review of the literature
    Murakami, J
    Fukushima, N
    Ueno, H
    Saito, T
    Watanabe, T
    Tanosaki, R
    Kobayashi, Y
    Matsuno, Y
    Tobinai, K
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2002, 75 (01) : 85 - 90
  • [29] Primary hepatic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type A case report and literature review
    Dong, Shuilin
    Chen, Lin
    Chen, Yifa
    Chen, Xiaoping
    MEDICINE, 2017, 96 (13)
  • [30] THE BCL-2 GENE IN PRIMARY B-CELL LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID-TISSUE (MALT)
    PAN, LX
    DISS, TC
    CUNNINGHAM, D
    ISAACSON, PG
    AMERICAN JOURNAL OF PATHOLOGY, 1989, 135 (01): : 7 - 11