Combination of novel systemic agents and radiotherapy for solid tumors - part I: An AIRO (Italian association of radiotherapy and clinical oncology) overview focused on treatment efficacy

被引：5

作者：

Arcangeli, Stefano ^{[1
,2
]}

Jereczek-Fossa, Barbara Alicia ^{[3
]}

Alongi, Filippo ^{[4
,5
]}

Aristei, Cynthia ^{[6
]}

Becherini, Carlotta ^{[7
]}

Belgioia, Liliana ^{[8
,9
]}

Buglione, Michela ^{[10
,11
]}

Caravatta, Luciana ^{[12
]}

D'Angelillo, Rolando Maria ^{[13
]}

Filippi, Andrea Riccardo ^{[14
]}

Fiore, Michele ^{[13
]}

Genovesi, Domenico ^{[12
]}

Greco, Carlo ^{[13
]}

Livi, Lorenzo ^{[7
]}

Magrini, Stefano Maria ^{[10
,11
]}

Marvaso, Giulia ^{[3
]}

Mazzola, Rosario ^{[4
,5
]}

Meattini, Icro ^{[7
]}

Merlotti, Anna ^{[15
]}

Palumbo, Isabella ^{[6
]}

Pergolizzi, Stefano ^{[16
]}

Ramella, Sara ^{[13
]}

Ricardi, Umberto ^{[17
]}

Russi, Elvio ^{[15
]}

Trovo, Marco ^{[18
]}

Sindoni, Alessandro ^{[20
]}

Valentini, Vincenzo ^{[19
]}

Corvo, Renzo ^{[8
,9
]}

机构：

[1] Policlin S Gerardo, Dept Radiat Oncol, Milan, Italy

[2] Univ Milano Bicocca, Milan, Italy

[3] IEO European Inst Oncol IRCCS, Dept Radiat Oncol, Milan, Italy

[4] Sacro Cuore Don Calabria Canc Care Ctr, Dept Radiat Oncol, Negrar Verona, Italy

[5] Univ Brescia, Brescia, Italy

[6] Univ Perugia, Perugia Gen Hosp, Dept Surg & Biomed Sci, Radiat Oncol Sect, Perugia, Italy

[7] Univ Florence, Dept Expt & Clin Biomed Sci, Radiotherapy Unit, Florence, Italy

[8] Osped Policlin San Martino, Dept Radiat Oncol, Genoa, Italy

[9] Univ Genoa, Genoa, Italy

[10] Univ Brescia, Dept Radiat Oncol, Brescia, Italy

[11] Spedali Civili Hosp, Brescia, Italy

[12] Univ G dAnnunzio, SS Annunziata Hosp, Dept Radiat Oncol, Chieti, Italy

[13] Campus Biomed Univ, Radiotherapy Unit, Rome, Italy

[14] Fdn IRCCS Policlin San Matteo, Dept Radiat Oncol, Pavia, Italy

[15] S Croce & Carle Teaching Hosp, Dept Radiat Oncol, Cuneo, Italy

[16] Univ Messina, Dept Biomed Sci & Morphol & Funct Images, Messina, Italy

[17] Univ Turin, Dept Oncol, Turin, Italy

[18] Azienda Sanit Univ Integrata Udine, Dept Radiat Oncol, Udine, Italy

[19] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli, Gemelli Adv Radiat Therapy Ctr, Rome, Italy

[20] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, Rome, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2019年 / 134卷

关键词：

RANDOMIZED PHASE-II; EPIDERMAL-GROWTH-FACTOR; ADVANCED RECTAL-CANCER; RESISTANT PROSTATE-CANCER; SQUAMOUS-CELL CARCINOMA; LOCALLY ADVANCED HEAD; MELANOMA BRAIN METASTASES; 3-DIMENSIONAL CONFORMAL RADIOTHERAPY; STEREOTACTIC BODY RADIOTHERAPY; HEDGEHOG PATHWAY INHIBITOR;

D O I：

10.1016/j.critrevonc.2018.11.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Over the past century, technologic advances have promoted the evolution of radiation therapy into a precise treatment modality allowing for the maximal administration of dose to tumors while sparing normal tissues. In parallel with this technological maturation, the rapid expansion in understanding the basic biology and heterogeneity of cancer has led to the development of several compounds that target specific pathways. Many of them are in advanced steps of clinical development for combination treatments with radiotherapy, and can be incorporated into radiation oncology practice for a personalized approach to maximize the therapeutic gain. This review describes the rationale for combining novel agents with radiation, and provides an overview of the current landscape focused on treatment efficacy.

引用

页码：87 / 103

页数：17

共 17 条

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