Experimental evidence for long-term programming effects of early diet

被引:0
|
作者
Symonds, ME [1 ]
Budge, H [1 ]
Stephenson, T [1 ]
Gardner, DS [1 ]
机构
[1] Univ Nottingham Hosp, Ctr Reprod & Early Life, Inst Clin Res, Nottingham NG7 2UH, England
来源
EARLY NUTRITION AND ITS LATER CONSEQUENCES: NEW OPPORTUNITIES: PERINATAL PROGRAMMING OF ADULT HEALTH - EC SUPPORTED RESEARCH | 2005年 / 569卷
关键词
fetal development; mRNA; leptin; embryo; stress; kidney; fat; LOW-PROTEIN-DIET; RENIN-ANGIOTENSIN SYSTEM; PRENATAL EXPOSURE; NUTRITIONAL MANIPULATION; ADULT HYPERTENSION; MATERNAL NUTRITION; BIRTH-WEIGHT; PREGNANCY; OBESITY; GROWTH;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Nutritional manipulation targeted at specific periods of embryo or placental development can result in substantial changes in fetal organ development despite no effects on fetal weight. In particular, kidney and fat mass are greater in nutrient restricted offspring in conjunction with higher mRNA abundance for leptin, insulin-like growth factors I/II and glucocorticoid receptors. As young adults, nutrient restricted offspring exhibit a blunting of the cardiovascular baroreflex. They also demonstrate increased plasma leptin following sympathetic stimulation, not observed in controls, indicating resetting of adipocyte sensitivity to stress. In conclusion, global nutrient restriction confined to periods of early development programmes adult physiology in a manner that may predispose to later disease given the appropriate environmental stimuli.
引用
收藏
页码:24 / 32
页数:9
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