Parkinson's disease and enhanced inflammatory response

被引：126

作者：

Stojkovska, Iva ^{[1
]}

Wagner, Brandon M. ^{[1
]}

Morrison, Brad E. ^{[1
]}

机构：

[1] Boise State Univ, Dept Biol Sci, Boise, ID 83725 USA

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 240卷 / 11期

关键词：

Parkinson's disease; neuroinflammation; inflammation; disease models; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; BLOOD-BRAIN-BARRIER; SYNUCLEIN TRANSGENIC MICE; ALPHA-SYNUCLEIN; MICROGLIAL ACTIVATION; DOPAMINERGIC-NEURONS; SUBSTANTIA-NIGRA; MITOCHONDRIAL DYSFUNCTION; INTRANIGRAL INJECTION; INTERFERON-GAMMA;

D O I：

10.1177/1535370215576313

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Parkinson's disease (PD) is the first and second most prevalent motor and neurodegenerative disease, respectively. The clinical symptoms of PD result from a loss of midbrain dopaminergic (DA) neurons. However, the molecular cause of DA neuron loss remains elusive. Mounting evidence implicates enhanced inflammatory response in the development and progression of PD pathology. This review examines current research connecting PD and inflammatory response.

引用

页码：1387 / 1395

页数：9

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