Dupilumab normalizes expression of genes associated with fibrosis, remodeling, and barrier function in patients with eosinophilic esophagitis

被引:0
|
作者
Hamilton, J. D. [1 ]
Lim, W. K. [1 ]
Hamon, S. [1 ]
Rothenberg, M. E. [2 ,3 ]
Collins, M. H. [2 ,3 ]
Chehade, M. [4 ]
Harel, S. [1 ]
Wipperman, M. F. [1 ]
Hirano, I [5 ]
Dellon, E. S. [6 ]
Brian, W. [7 ]
Mannent, L. P. [8 ]
Graham, N. M. H. [1 ]
Patel, N. [7 ]
Ruddy, M. [1 ]
Radin, A. [1 ]
机构
[1] Regeneron Pharmaceut Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
[2] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA
[3] Univ Cincinnati, Coll Med, Cincinnati, OH USA
[4] Icahn Sch Med Mt Sinai, Mt Sinai Ctr Eosinophil Disorders, New York, NY 10029 USA
[5] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
[6] Univ N Carolina, Sch Med, Chapel Hill, NC 27515 USA
[7] Sanofi, Bridgewater, MA USA
[8] Sanofi, Chilly Mazarin, France
关键词
D O I
暂无
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
0430
引用
收藏
页码:11 / 12
页数:2
相关论文
共 50 条
  • [31] Expression of mast cell-associated genes is upregulated in adult eosinophilic esophagitis and responds to steroid or dietary therapy
    Blatman, Karen S. Hsu
    Gonsalves, Nirmala
    Hirano, Ikuo
    Bryce, Paul J.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (05) : 1307 - U335
  • [32] A role for age-associated alterations in esophageal epithelium in eosinophilic esophagitis-associated fibrosis
    Klochkova, Alena
    Fuller, Annie D.
    Miller, Riley
    Karami, Adam L.
    Panchani, Surali R.
    Natarajan, Shruthi
    Mu, Anbin
    Jackson, Jazmyne L.
    Klein-Szanto, Andres J.
    Muir, Amanda B.
    Whelan, Kelly A.
    FRONTIERS IN ALLERGY, 2022, 3
  • [33] Dupilumab Normalized The Expression Of Genes Dysregulated In Eosinophilic Esophagitis (EoE) In Esophageal Biopsies From A Clinical Trial Of Children Aged 1-11 Years
    Rothenberg, Marc
    Lim, Wei Keat
    Wipperman, Matthew
    Chehade, Mirna
    Dellon, Evan
    Hundal, Navneet Virk
    Schroeder, Shauna
    Parrish, Christopher
    Liu, Ruiqi
    Laws, Elizabeth
    Mortensen, Eric
    Glotfelty, Lila
    Shabbir, Arsalan
    Hicks, Alexandra
    Hamilton, Jennifer
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2024, 153 (02) : AB147 - AB147
  • [34] Correlation of the Eosinophilic Histopathological Scoring System with Esophageal Gene Expression in Patients with Eosinophilic Esophagitis
    Shoda, Tetsuo
    Wen, Ting
    Caldwell, Julie M.
    Kuhl, Jonathan
    Aceves, Seema S.
    Bonis, Peter
    Capocelli, Kelley E.
    Collins, Margaret H.
    Dellon, Evan S.
    Falk, Gary W.
    Furuta, Glenn
    Gonsalves, Nirmala
    Gupta, Sandeep
    Hirano, Ikuo
    Leung, John
    Menard-Katcher, Paul
    Spergel, Jonathan M.
    Wershil, Barry K.
    Yang, Guang-Yu
    Rothenberg, Marc E.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2018, 141 (02) : AB138 - AB138
  • [35] DISRUPTION OF ESOPHAGEAL EPITHELIAL BARRIER FUNCTION AND ITS CORRELATION WITH EOSINOPHIL INFILTRATION IN EOSINOPHILIC ESOPHAGITIS
    Li, Min
    Oshima, Tadayuki
    Nishii, Norio
    Horikawa, Tomoki
    Michigami, Yuki
    Kitayama, Yoshitaka
    Eda, Hirotsugu
    Nakamura, Kumiko
    Tamura, Akio
    Ogawa, Tomohiro
    Yamasaki, Takahisa
    Okugawa, Takuya
    Kondo, Takashi
    Kono, Tomoaki
    Tozawa, Katsuyuki
    Tomita, Toshihiko
    Fukui, Hirokazu
    Watari, Jiro
    Miwa, Hiroto
    GASTROENTEROLOGY, 2019, 156 (06) : S731 - S731
  • [36] FIRST REPORT OF COEXISTING CYSTIC FIBROSIS AND EOSINOPHILIC ESOPHAGITIS IN TWO PEDIATRIC PATIENTS
    Waterhouse, K.
    Albers, G.
    Knutsen, A.
    Teckman, J.
    Becker, B.
    ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2009, 103 (05) : A107 - A107
  • [37] REAL-WORLD EFFICACY OF DUPILUMAB IN SEVERE, TREATMENT-REFRACTORY, AND FIBROSTENOTIC PATIENTS WITH EOSINOPHILIC ESOPHAGITIS
    Lee, Christopher J.
    Dellon, Evan S.
    GASTROENTEROLOGY, 2023, 164 (06) : S345 - S346
  • [38] Real-World Efficacy of Dupilumab in Severe, Treatment-Refractory, and Fibrostenotic Patients With Eosinophilic Esophagitis
    Lee, Christopher J.
    Dellon, Evan S.
    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2024, 22 (02) : 252 - 258
  • [39] AGE-ASSOCIATED DECLINE IN ESOPHAGEAL AUTOPHAGY FLUX CONTRIBUTES TO FIBROSIS IN EOSINOPHILIC ESOPHAGITIS
    Whelan, Kelly A.
    Godwin, Bridget C.
    Wilkins, Benjamin J.
    Chandramouleeswaran, Prasanna
    Sharma, Medha
    Benitez, Alain
    Gross, Jonathan
    DeMarshall, Maureen
    Klein-Szanto, Andres
    Spergel, Jonathan
    Falk, Gary W.
    Muir, Amanda B.
    Nakagawa, Hiroshi
    GASTROENTEROLOGY, 2017, 152 (05) : S856 - S856
  • [40] Acid suppression normalizes the expression of mucosal repair associated genes in the esophageal epithelium of GERD patients
    Vries de, Durk
    Ter linde, Jose
    Van herwaarden, Margot
    Shephard, Pierre
    Geng, Michael
    Hofmann, Hans peter
    Klein, Thomas
    Postius, Stefan
    Schwartz, Matthijs P.
    Samsom, Melvin
    GASTROENTEROLOGY, 2007, 132 (04) : A122 - A122