Dupilumab normalizes expression of genes associated with fibrosis, remodeling, and barrier function in patients with eosinophilic esophagitis

被引:0
|
作者
Hamilton, J. D. [1 ]
Lim, W. K. [1 ]
Hamon, S. [1 ]
Rothenberg, M. E. [2 ,3 ]
Collins, M. H. [2 ,3 ]
Chehade, M. [4 ]
Harel, S. [1 ]
Wipperman, M. F. [1 ]
Hirano, I [5 ]
Dellon, E. S. [6 ]
Brian, W. [7 ]
Mannent, L. P. [8 ]
Graham, N. M. H. [1 ]
Patel, N. [7 ]
Ruddy, M. [1 ]
Radin, A. [1 ]
机构
[1] Regeneron Pharmaceut Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
[2] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA
[3] Univ Cincinnati, Coll Med, Cincinnati, OH USA
[4] Icahn Sch Med Mt Sinai, Mt Sinai Ctr Eosinophil Disorders, New York, NY 10029 USA
[5] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
[6] Univ N Carolina, Sch Med, Chapel Hill, NC 27515 USA
[7] Sanofi, Bridgewater, MA USA
[8] Sanofi, Chilly Mazarin, France
关键词
D O I
暂无
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
0430
引用
收藏
页码:11 / 12
页数:2
相关论文
共 50 条
  • [21] Identification of Epithelial Mesenchymal Transition in Eosinophilic Esophagitis and Its Relationship to Esophageal Remodeling and Fibrosis
    Akhtar, Noorain
    Woodruff, Samantha A.
    Mukkada, Vincent A.
    Fillon, Sophie A.
    Masterson, Joanne C.
    Kagalwalla, Amir F.
    Parashette, Kalyan Ray
    Jun, Christine
    Lee, James J.
    Furuta, Glenn T.
    Ackerman, Steven J.
    GASTROENTEROLOGY, 2010, 138 (05) : S172 - S172
  • [22] Effect of treatment on esophageal epithelial barrier function and inflammation in eosinophilic esophagitis
    Chen, Junji
    Oshima, Tadayuki
    Nakai, Keisuke
    Kitayama, Yoshitaka
    Hara, Ken
    Tamura, Akio
    Fukushima, Masashi
    Okugawa, Takuya
    Tomita, Toshihiko
    Fukui, Hirokazu
    Miwa, Hiroto
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2021, 36 : 204 - 204
  • [23] A Gap in Care Leads to Progression of Fibrosis in Eosinophilic Esophagitis Patients
    Chang, Nicole C.
    Thakkar, Kisan P.
    Ketchem, Corey J.
    Eluri, Swathi
    Reed, Craig C.
    Dellon, Evan S.
    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2022, 20 (08) : 1701 - +
  • [24] A GAP IN CARE LEADS TO PROGRESSION OF FIBROSIS IN EOSINOPHILIC ESOPHAGITIS PATIENTS
    Chang, Nicole C.
    Thakkar, Kisan
    Ketchem, Corey J.
    Eluri, Swathi
    Reed, Craig C.
    Dellon, Evan S.
    GASTROENTEROLOGY, 2021, 160 (06) : S254 - S255
  • [25] Disease activity in eosinophilic esophagitis is associated with impaired esophageal barrier integrity
    Warners, Marijn J.
    van Rhijn, Bram D.
    Verheij, Joanne
    Smout, Andreas J. P. M.
    Bredenoord, Albert J.
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2017, 313 (03): : G230 - G238
  • [26] SOCIOECONOMIC DISPARITIES IMPACTING THE CHARACTERISTICS AND OUTCOME FOR PEDIATRIC PATIENTS WITH EOSINOPHILIC ESOPHAGITIS RECEIVING DUPILUMAB
    Xi, Dong
    Carlisle, Annette
    Lieberman, Jay
    GASTROENTEROLOGY, 2024, 166 (05) : S1233 - S1233
  • [27] Tissue remodeling in patients with eosinophilic esophagitis: What lies beneath the surface?
    Aceves, Seema S.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 128 (05) : 1047 - 1049
  • [28] Esophageal Compliance Quantifies Epithelial Remodeling in Pediatric Patients With Eosinophilic Esophagitis
    Hassan, Maheen
    Aceves, Seema
    Dohil, Ranjan
    Gharibans, Armen
    Newbury, Robert
    Proudfoot, James
    Mousa, Hayat
    JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2019, 68 (04): : 559 - 565
  • [29] Eosinophilic esophagitis-associated epithelial remodeling may limit esophageal carcinogenesis
    Fuller, Annie D.
    Karami, Adam L.
    Kabir, Mohammad Faujul
    Klochkova, Alena
    Jackson, Jazmyne L.
    Mu, Anbin
    Tan, Yinfei
    Klein-Szanto, Andres J.
    Whelan, Kelly A.
    FRONTIERS IN ALLERGY, 2023, 4
  • [30] Dupilumab Improves Health-Related Quality of Life and a Range of Symptoms in Patients With Eosinophilic Esophagitis
    Spergel, Jonathan M.
    Chehade, Mirna
    Dellon, Evan S.
    Bredenoord, Albert J.
    Sun, Xian
    Glotfelty, Lila
    Shabbir, Arsalan
    Tilton, Sarette T.
    Mccann, Eilish
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2024, 119 (12): : 2398 - 2407