Theta burst stimulation over premotor cortex in Parkinson's disease: an explorative study on manual dexterity

被引:7
|
作者
Vanbellingen, Tim [1 ,2 ,3 ,4 ]
Wapp, Manuela [5 ]
Stegmayer, Katharina [6 ]
Bertschi, Manuel [2 ,3 ]
Abela, Eugenio [5 ]
Kubel, Stefanie [1 ]
Nyffeler, Thomas [1 ,2 ,3 ,4 ]
Muri, Rene [2 ,3 ,4 ]
Walther, Sebastian [6 ]
Nef, Tobias [4 ,7 ]
Hallett, Mark [8 ]
Bohlhalter, Stephan [1 ,2 ,3 ]
机构
[1] Luzerner Kantonsspital, Neurol & Neurorehabil Ctr, Luzern, Switzerland
[2] Univ Hosp Bern, Inselspital, Percept & Eye Movement Lab, Dept Neurol, Bern, Switzerland
[3] Univ Hosp Bern, Inselspital, Percept & Eye Movement Lab, Dept Clin Res, Bern, Switzerland
[4] Univ Bern, ARTORG Ctr Biomed Engn Res, Bern, Switzerland
[5] Univ Hosp Bern, Inselspital, Inst Diagnost & Intervent Neuroradiol, SCAN, Bern, Switzerland
[6] Univ Hosp Psychiat, Bern, Switzerland
[7] Univ Bern, Gerontechnol & Rehabil Grp, Bern, Switzerland
[8] NINDS, Human Motor Control Sect, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
基金
瑞士国家科学基金会;
关键词
Manual dexterity; Premotor cortex; Limb kinetic apraxia; Parkinson's disease; Coin rotation; TRANSCRANIAL MAGNETIC STIMULATION; LIMB-KINETIC APRAXIA; EXCITABILITY;
D O I
10.1007/s00702-016-1614-6
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Dorsal pre-motor cortex (PMd) is thought to play a role in fine motor control. The aim of the present study was to investigate whether inhibitory or excitatory stimulation of PMd would have an impact on manual dexterity in Parkinson's disease (PD). Fifteen patients with PD participated in this study. High resolution structural MRI was used for neuro-navigated TBS. Participants were targeted with one train of TBS in three experimental sessions: sham stimulation over vertex, continuous TBS (cTBS) over PMd and intermittent TBS (iTBS) over PMd, respectively. Dexterity was measured by a coin rotation task (CRT), which is a valid measure to detect limb kinetic apraxia (LKA). Neither cTBS or iTBS significantly interfered with CRT. Post hoc sub-analysis in a group of PD patients (n = 5) with stronger baseline impairment, indicating LKA, revealed further deterioration of dexterous performance for the cTBS condition (p = 0.04). This sham controlled pilot study demonstrates that TBS over PMd does not significantly interfere with dexterity in PD. However, patients with dexterous impairment qualifying for LKA may be more susceptible to TBS.
引用
收藏
页码:1387 / 1393
页数:7
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