Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging

被引：72
|
作者：
Fatieiev, Y. [1 ]
Croissant, J. G. [1 ]
Julfakyan, K. [1 ]
Deng, L. [1 ]
Anjum, D. H. [2 ]
Gurinov, A. [2 ]
Khashab, N. M. [1 ]
机构：
[1] King Abdullah Univ Sci & Technol, Adv Membranes & Porous Mat Ctr, Smart Hybrid Mat Lab, Thuwal 239556900, Saudi Arabia
[2] King Abdullah Univ Sci & Technol, Adv Nanofabricat Imaging & Characterizat Lab, Thuwal 239556900, Saudi Arabia
来源：
NANOSCALE | 2015年 / 7卷 / 37期
关键词：
MESOPOROUS ORGANOSILICA NANOPARTICLES; DRUG-DELIVERY; POLYSILSESQUIOXANE NANOPARTICLES; SILICA NANOPARTICLES; THERAPY; CELLS; NANOCARRIERS; COMBINATION; SYSTEMS; CHARGE;
D O I：
10.1039/c5nr03065j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.
引用
收藏
页码：15046 / 15050
页数：5
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