Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging

被引：72

作者：

Fatieiev, Y. ^{[1
]}

Croissant, J. G. ^{[1
]}

Julfakyan, K. ^{[1
]}

Deng, L. ^{[1
]}

Anjum, D. H. ^{[2
]}

Gurinov, A. ^{[2
]}

Khashab, N. M. ^{[1
]}

机构：

[1] King Abdullah Univ Sci & Technol, Adv Membranes & Porous Mat Ctr, Smart Hybrid Mat Lab, Thuwal 239556900, Saudi Arabia

[2] King Abdullah Univ Sci & Technol, Adv Nanofabricat Imaging & Characterizat Lab, Thuwal 239556900, Saudi Arabia

来源：

NANOSCALE | 2015年 / 7卷 / 37期

关键词：

MESOPOROUS ORGANOSILICA NANOPARTICLES; DRUG-DELIVERY; POLYSILSESQUIOXANE NANOPARTICLES; SILICA NANOPARTICLES; THERAPY; CELLS; NANOCARRIERS; COMBINATION; SYSTEMS; CHARGE;

D O I：

10.1039/c5nr03065j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.

引用

页码：15046 / 15050

页数：5

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