Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging

被引：73

作者：

Fatieiev, Y. ^{[1
]}

Croissant, J. G. ^{[1
]}

Julfakyan, K. ^{[1
]}

Deng, L. ^{[1
]}

Anjum, D. H. ^{[2
]}

Gurinov, A. ^{[2
]}

Khashab, N. M. ^{[1
]}

机构：

[1] King Abdullah Univ Sci & Technol, Adv Membranes & Porous Mat Ctr, Smart Hybrid Mat Lab, Thuwal 239556900, Saudi Arabia

[2] King Abdullah Univ Sci & Technol, Adv Nanofabricat Imaging & Characterizat Lab, Thuwal 239556900, Saudi Arabia

来源：

NANOSCALE | 2015年 / 7卷 / 37期

关键词：

MESOPOROUS ORGANOSILICA NANOPARTICLES; DRUG-DELIVERY; POLYSILSESQUIOXANE NANOPARTICLES; SILICA NANOPARTICLES; THERAPY; CELLS; NANOCARRIERS; COMBINATION; SYSTEMS; CHARGE;

D O I：

10.1039/c5nr03065j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.

引用

收藏

页码：15046 / 15050

页数：5

相关论文

共 50 条

[1] Smart drug delivery systems: from fundamentals to the clinic [J].

Alvarez-Lorenzo, Carmen ;

Concheiro, Angel .

CHEMICAL COMMUNICATIONS, 2014, 50 (58) :7743-7765

[2] DNA encapsulated magnesium and manganous phosphate nanoparticles: potential non-viral vectors for gene delivery [J].

Bhakta, G ;

Mitra, S ;

Maitra, A .

BIOMATERIALS, 2005, 26 (14) :2157-2163

[3] Photoresponsive polymersomes as smart, triggerable nanocarriers [J].

Cabane, Etienne ;

Malinova, Violeta ;

Menon, Sindhu ;

Palivan, Cornelia G. ;

Meier, Wolfgang .

SOFT MATTER, 2011, 7 (19) :9167-9176

[4] Strategies for advancing cancer nanomedicine [J].

Chauhan, Vikash P. ;

Jain, Rakesh K. .

NATURE MATERIALS, 2013, 12 (11) :958-962

[5] Ordered Hybrids from Template-Free Organosilane Self-Assembly [J].

Chemtob, Abraham ;

Ni, Lingli ;

Croutxe-Barghorn, Celine ;

Boury, Bruno .

CHEMISTRY-A EUROPEAN JOURNAL, 2014, 20 (07) :1790-1806

[6] Hollow Mesoporous Organosilica Nanoparticles: A Generic Intelligent Framework-Hybridization Approach for Biomedicine [J].

Chen, Yu ;

Meng, Qingshuo ;

Wu, Meiying ;

Wang, Shige ;

Xu, Pengfei ;

Chen, Hangrong ;

Li, Yaping ;

Zhang, Lingxia ;

Wang, Lianzhou ;

Shi, Jianlin .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (46) :16326-16334

[7] The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles 3T3-L1 cells and human mesenchymal stem cells [J].

Chung, Tsai-Hua ;

Wu, Si-Han ;

Yao, Ming ;

Lu, Chen-Wen ;

Lin, Yu-Shen ;

Hung, Yann ;

Mou, Chung-Yuan ;

Chen, Yao-Chang ;

Huang, Dong-Ming .

BIOMATERIALS, 2007, 28 (19) :2959-2966

[8]

Corma A., 2009, ANGEW CHEM, V121, P6365, DOI [10.1002/ange.200902208, DOI 10.1002/ANGE.200902208]

[9] Mechanised nanoparticles for drug delivery [J].

Coti, Karla K. ;

Belowich, Matthew E. ;

Liong, Monty ;

Ambrogio, Michael W. ;

Lau, Yuen A. ;

Khatib, Hussam A. ;

Zink, Jeffrey I. ;

Khashab, Niveen M. ;

Stoddart, J. Fraser .

NANOSCALE, 2009, 1 (01) :16-39

[10] Self-Assembly of Bridged Silsesquioxanes: Modulating Structural Evolution via Cooperative Covalent and Noncovalent Interactions [J].

Creff, Gaelle ;

Pichon, Benoit P. ;

Blanc, Christophe ;

Maurin, David ;

Sauvajol, Jean-Louis ;

Carcel, Carole ;

Moreau, Joel J. E. ;

Roy, Pascale ;

Bartlett, John R. ;

Man, Michel Wong Chi ;

Bantignies, Jean-Louis .

LANGMUIR, 2013, 29 (18) :5581-5588

← 1 2 3 4 5 →