Amberlyst A21: A reusable solid catalyst for green synthesis of pyran annulated heterocycles at room temperature

被引：33

作者：

Bihani, Manisha ^{[1
]}

Bora, Pranjal P. ^{[1
]}

Bez, Ghanashyam ^{[1
]}

Askari, Hassan ^{[1
]}

机构：

[1] North Eastern Hill Univ, Dept Chem, Shillong 793022, Meghalaya, India

来源：

COMPTES RENDUS CHIMIE | 2013年 / 16卷 / 05期

关键词：

Pyrans; MCRs; Amberlyst A21; Green synthesis; THROUGHPUT SCREENING ASSAY; APOPTOSIS INDUCERS; DERIVATIVES; SERIES; DISCOVERY; A-21; 4-ARYL-4H-CHROMENES;

D O I：

10.1016/j.crci.2012.11.018

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amberlyst A21, a neutral ion-exchange resin and a solid base, can catalyze the three-component reaction of aldehyde and malononitrile with various active methylene compounds at room temperature to synthesize a range of pharmaceutically important pyran annulated heterocycles. Use of the solid base could generate a highly green protocol by eliminating chromatographic purification that involves hazardous organic solvents, and facilitate easy recovery and reusability of the catalyst. (C) 2012 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：419 / 426

页数：8

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