Background-Fetuin-A may be involved in the etiology of coronary heart disease (CHD) through opposing pathways (ie, promoting insulin resistance and inhibiting ectopic calcification). We aimed to explicitly examine whether systemic inflammation, a factor leading to elevated vascular calcification, may modify the association between fetuin-A and CHD risk. Method and Results-During 16 years of follow-up (1990-2006), we prospectively identified and confirmed 466 incident fatal or nonfatal CHD case in the Nurses' Health Study. For each case, 1 healthy control was selected using risk-set sampling from 26 245 eligible participants. Cases and controls were matched for age, smoking status, fasting status, and date of blood draw. After multivariate adjustment for lifestyle factors, body mass index, diet, and blood lipids, fetuin-A levels were not associated with CHD risk in the whole population: odds ratio (OR) (95% CI) comparing extreme quintiles of fetuin-A was 0.79 (0.44 to 1.40). However, a significant inverse association was observed among participants with higher C-reactive protein levels (Pinteraction=0.04). The OR (95% CI) comparing highest versus lowest quintiles of fetuin-A was 0.50 (0.26 to 0.97; Ptrend=0.004) when C-reactive protein levels were above population median (0.20 mg/dL), whereas among the remainder of the participants, the corresponding OR (95% CI) was 1.09 (0.58 to 2.05; Ptrend=0.75). Conclusions-In this population of US women, fetuin-A levels were associated with lower CHD risk when C-reactive protein levels were high, but null association was observed among participants with lower C-reactive protein levels. This divergent pattern of association needs replication in future studies.
机构:
Atlanta VAMC, 1462 Clifton Rd, Atlanta, GA 30322 USA
Emory Clin Cardiovasc Res Inst, Atlanta, GA 30322 USAAtlanta VAMC, 1462 Clifton Rd, Atlanta, GA 30322 USA
机构:
Guangxi Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanning 530021, Guangxi, Peoples R ChinaGuangxi Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanning 530021, Guangxi, Peoples R China
Miao, Liu
Deng, Guo-Xiong
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Guangxi Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanning 530021, Guangxi, Peoples R ChinaGuangxi Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanning 530021, Guangxi, Peoples R China
Deng, Guo-Xiong
Yin, Rui-Xing
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机构:
Guangxi Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanning 530021, Guangxi, Peoples R China
Guangxi Key Lab Base Precis Med Cardiocerebrovasc, Nanning, Guangxi, Peoples R China
Guangxi Clin Res Ctr Cardiocerebrovasc Dis, Nanning, Guangxi, Peoples R ChinaGuangxi Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanning 530021, Guangxi, Peoples R China
Yin, Rui-Xing
Nie, Rong-Jun
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机构:
Guangxi Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanning 530021, Guangxi, Peoples R ChinaGuangxi Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanning 530021, Guangxi, Peoples R China
Nie, Rong-Jun
Yang, Shuo
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机构:
Guangxi Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanning 530021, Guangxi, Peoples R ChinaGuangxi Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanning 530021, Guangxi, Peoples R China
Yang, Shuo
Wang, Yong
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机构:
Liuzhou Peoples Hosp, Dept Cardiol, Liuzhou, Guangxi, Peoples R ChinaGuangxi Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanning 530021, Guangxi, Peoples R China
Wang, Yong
Li, Hui
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机构:
Guangxi Med Univ, Clin Lab, Affiliated Canc Hosp, Nanning, Guangxi, Peoples R ChinaGuangxi Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanning 530021, Guangxi, Peoples R China
机构:
Univ S Carolina, S Carolina Canc Prevent & Control Program, Columbia, SC 29208 USA
Univ S Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA
Univ S Carolina, Arnold Sch Publ Hlth, Dept Environm Hlth Sci, Columbia, SC 29208 USA
Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Exposure Epidemiol & Risk Program, Boston, MA 02115 USAUniv S Carolina, S Carolina Canc Prevent & Control Program, Columbia, SC 29208 USA
Puett, Robin C.
Hart, Jaime E.
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h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Exposure Epidemiol & Risk Program, Boston, MA 02115 USA
Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA
Harvard Univ, Sch Med, Boston, MA USAUniv S Carolina, S Carolina Canc Prevent & Control Program, Columbia, SC 29208 USA
Hart, Jaime E.
Yanosky, Jeff D.
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h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Exposure Epidemiol & Risk Program, Boston, MA 02115 USAUniv S Carolina, S Carolina Canc Prevent & Control Program, Columbia, SC 29208 USA
Yanosky, Jeff D.
Paciorek, Christopher
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h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USAUniv S Carolina, S Carolina Canc Prevent & Control Program, Columbia, SC 29208 USA
Paciorek, Christopher
Schwartz, Joel
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h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Exposure Epidemiol & Risk Program, Boston, MA 02115 USA
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USAUniv S Carolina, S Carolina Canc Prevent & Control Program, Columbia, SC 29208 USA
Schwartz, Joel
Suh, Helen
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h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Exposure Epidemiol & Risk Program, Boston, MA 02115 USAUniv S Carolina, S Carolina Canc Prevent & Control Program, Columbia, SC 29208 USA
Suh, Helen
Speizer, Frank E.
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h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Exposure Epidemiol & Risk Program, Boston, MA 02115 USA
Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA
Harvard Univ, Sch Med, Boston, MA USAUniv S Carolina, S Carolina Canc Prevent & Control Program, Columbia, SC 29208 USA
Speizer, Frank E.
Laden, Francine
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h-index: 0
机构:
Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Exposure Epidemiol & Risk Program, Boston, MA 02115 USA
Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA
Harvard Univ, Sch Med, Boston, MA USA
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USAUniv S Carolina, S Carolina Canc Prevent & Control Program, Columbia, SC 29208 USA
机构:
Univ Calif San Francisco, Div Cardiol, Seattle, WA USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Parikh, Nisha I.
Jeppson, Rebecca P.
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h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Jeppson, Rebecca P.
Berger, Jeffrey S.
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机构:
NYU, Sch Med, Vasc Surg, Cardiol,Hematol, New York, NY 10003 USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Berger, Jeffrey S.
Eaton, Charles B.
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h-index: 0
机构:
Brown Univ, Dept Family Med, Providence, RI 02912 USA
Brown Univ, Dept Epidemiol, Providence, RI 02912 USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Eaton, Charles B.
Kroenke, Candyce H.
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机构:
Kaiser Permanente Div Res, Oakland, CA USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Kroenke, Candyce H.
LeBlanc, Erin S.
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h-index: 0
机构:
Kaiser Permanente Ctr Hlth Res, Portland, OR USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
LeBlanc, Erin S.
Lewis, Cora E.
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h-index: 0
机构:
Univ Alabama Birmingham, Birmingham, AL USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Lewis, Cora E.
Loucks, Eric B.
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h-index: 0
机构:
Brown Univ, Sch Publ Hlth, Dept Epidemiol, Providence, RI 02912 USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Loucks, Eric B.
Parker, Donna R.
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Dept Family Med, Providence, RI 02912 USA
Brown Univ, Dept Epidemiol, Providence, RI 02912 USA
Brown Univ, Mem Hosp Rhode Isl, Ctr Primary Care & Prevent, Pawtucket, RI 02860 USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Parker, Donna R.
Rillamas-Sun, Eileen
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h-index: 0
机构:
Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Rillamas-Sun, Eileen
Ryckman, Kelli K.
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机构:
Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Ryckman, Kelli K.
Waring, Molly E.
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机构:
Univ Massachusetts, Sch Med, Dept Quantitat Hlth Sci, Div Epidemiol Chron Dis & Vulnerable Populat, Worcester, MA USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Waring, Molly E.
Schenken, Robert S.
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h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, San Antonio, TX 78229 USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Schenken, Robert S.
Johnson, Karen C.
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h-index: 0
机构:
Univ Tennessee, Ctr Hlth Sci, Dept Prevent Med, Memphis, TN 38163 USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Johnson, Karen C.
Edstedt-Bonamy, Anna-Karin
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机构:
Karolinska Inst, Clin Epidemiol Unit, Stockholm, SwedenUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Edstedt-Bonamy, Anna-Karin
Allison, Matthew A.
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机构:
USCD, Dept Family Med, La Jolla, CA USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA
Allison, Matthew A.
Howard, Barbara V.
论文数: 0引用数: 0
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机构:
MedStar Hlth Res Inst, Hyattsville, MD USA
Georgetown Univ, Ctr Clin & Translat Sci, Washington, DC USAUniv Calif San Francisco, Div Cardiol, Seattle, WA USA