NP03, A LOW DOSE LITHIUM MICROEMULSION, IMPROVES MOTOR FUNCTION AND RESCUES STRIATAL PATHOLOGY WITHOUT TOXICITY IN THE YAC128 MOUSE MODEL OF HUNTINGTON'S DISEASE

被引：0
|
作者：
Pouladi, M. A. [1 ,2 ]
Brilluad, E. [3 ]
Xie, Y. [1 ,2 ]
Franciosi, S. [1 ,2 ]
Zhang, W-N [1 ,2 ]
Zapala, M. [1 ,2 ]
Compte, E. [3 ]
Poucheret, P. [3 ]
Maurel, J-C [3 ]
Neri, C. [4 ]
Hayden, M. R. [1 ,2 ]
机构：
[1] Univ British Columbia, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 1M9, Canada
[2] Child & Family Res Inst, Vancouver, BC, Canada
[3] Medesis Pharma, Baillargues, France
[4] Ctr Paul Broca, Neuronal Cell Biol & Pathol U857, INSERM, Paris, France
来源：
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2010年 / 81卷
关键词：
D O I：
10.1136/jnnp.2010.222596.13
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
引用
收藏
页码：A15 / A15
页数：1
相关论文
共 15 条
  • [1] NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease
    Pouladi, Mahmoud A.
    Brillaud, Elsa
    Xie, Yuanyun
    Conforti, Paola
    Graham, Rona K.
    Ehrnhoefer, Dagmar E.
    Franciosi, Sonia
    Zhang, Weining
    Poucheret, Patrick
    Compte, Elsa
    Maurel, Jean-Claude
    Zuccato, Chiara
    Cattaneo, Elena
    Neri, Christian
    Hayden, Michael R.
    NEUROBIOLOGY OF DISEASE, 2012, 48 (03) : 282 - 289
  • [2] Striosome-matrix pathology and motor deficits in the YAC128 mouse model of Huntington's disease
    Lawhorn, Collene
    Smith, Diane M.
    Brown, Lucy L.
    NEUROBIOLOGY OF DISEASE, 2008, 32 (03) : 471 - 478
  • [3] LAQUINIMOD RESCUES STRIATAL, CORTICAL AND WHITE MATTER PATHOLOGY AND RESULTS IN MODEST BEHAVIOURAL IMPROVEMENTS IN THE YAC128 MODEL OF HUNTINGTON'S DISEASE
    Miralles, Marta Garcia
    Hong, Xin
    Caron, Nicholas S.
    Tan, Liang Juin
    Huang, Yihui
    To, Xuan Vinh
    Lin, Rachel Yanping
    Franciosi, Sonia
    Papapetropoulos, Spyros
    Hayardeny, Liat
    Hayden, Michael R.
    Chuang, Kai-Hsiang
    Pouladi, Mahmoud A.
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2016, 87 : A92 - A93
  • [4] TREATMENT WITH ARIMOCLOMOL DOES NOT LEAD TO RESCUE OF MOTOR OR STRIATAL DEFICITS IN THE YAC128 MOUSE MODEL OF HUNTINGTON'S DISEASE
    Pouladi, M. A.
    Carroll, J.
    Santos, R. Dar
    Bertram, L.
    Hayden, M. R.
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2010, 81 : A14 - A14
  • [5] Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease
    Marta Garcia-Miralles
    Xin Hong
    Liang Juin Tan
    Nicholas S. Caron
    Yihui Huang
    Xuan Vinh To
    Rachel Yanping Lin
    Sonia Franciosi
    Spyros Papapetropoulos
    Liat Hayardeny
    Michael R. Hayden
    Kai-Hsiang Chuang
    Mahmoud A. Pouladi
    Scientific Reports, 6
  • [6] Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease
    Garcia-Miralles, Marta
    Hong, Xin
    Tan, Liang Juin
    Caron, Nicholas S.
    Huang, Yihui
    To, Xuan Vinh
    Lin, Rachel Yanping
    Franciosi, Sonia
    Papapetropoulos, Spyros
    Hayardeny, Liat
    Hayden, Michael R.
    Chuang, Kai-Hsiang
    Pouladi, Mahmoud A.
    SCIENTIFIC REPORTS, 2016, 6
  • [7] Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease
    Van Raamsdonk, JM
    Pearson, J
    Slow, EJ
    Hossain, SM
    Leavitt, BR
    Hayden, MR
    JOURNAL OF NEUROSCIENCE, 2005, 25 (16): : 4169 - 4180
  • [8] Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease
    Van Raamsdonk, JM
    Pearson, J
    Rogers, DA
    Lu, G
    Barakauskas, VE
    Barr, AM
    Honer, WG
    Hayden, MR
    Leavitt, BR
    EXPERIMENTAL NEUROLOGY, 2005, 196 (02) : 266 - 272
  • [9] INVESTIGATION OF THE EFFECT OF LATENT TOXOPLASMA GONDII INFECTION ON STRIATAL NEURODEGENERATION IN THE YAC128 MOUSE MODEL OF HUNTINGTON'S DISEASE
    Jenkins, T. K.
    Donley, D. W.
    Fox, J. H.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2018, 66 (01) : 210 - 210
  • [10] p35 HEMIZYGOSITY ACTIVATES Akt BUT DOES NOT IMPROVE MOTOR FUNCTION IN THE YAC128 MOUSE MODEL OF HUNTINGTON'S DISEASE
    Park, Kevin H. J.
    Franciosi, Sonia
    Parrant, Kristina
    Lu, Ge
    Leavitt, Blair R.
    NEUROSCIENCE, 2017, 352 : 79 - 87
12