Monitoring response to chemotherapy of non-Hodgkin's lymphoma xenografts by T2-weighted and diffusion-weighted MRI

被引:45
作者
Huang, Ming Q. [1 ]
Pickup, Stephen [1 ]
Nelson, David S. [1 ]
Qiao, Hui [1 ]
Xu, He N. [1 ]
Li, Lin Z. [1 ]
Zhou, Rong [1 ]
Delikatny, E. James [1 ]
Poptani, Harish [1 ]
Glickson, Jerry D. [1 ]
机构
[1] Univ Penn, Dept Radiol, Mol Imaging Lab, Philadelphia, PA 19104 USA
关键词
MRI; non-Hodgkin's lymphoma; chemotherapy; response; apparent diffusion coefficient; T-2;
D O I
10.1002/nbm.1261
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
An effective method for in vivo detection of early therapeutic response of patients with non-Hodgkin's lymphoma would enable personalized clinical management of cancer therapy and facilitate the design of optimal treatment regimens. This study evaluates the feasibility of T-weighted MRI (T2WI) and diffusion-weighted MRI (DWI) for in vivo detection of response of human diffuse large B-cell lymphoma xenografts in severe combined immunodeficient mice to chemotherapy. Each cycle of combination chemotherapy with cyclophosphamide, hydroxydoxorubicin, Oncovin, prednisone, and bryostatin 1 (CHOPB) was administered to tumor-carrying mice weekly for up to four cycles. T2WI and DWI were performed before the initiation of CHOPB and after each cycle of CHOPB. In order to corroborate the MRI results, histological analyses were carried out on control tumors and treated tumors after completion of all MRI studies. DWI revealed a significant (P < 0.03) increase in the mean apparent diffusion coefficient in CHOPB-treated tumors as early as 1 week after initiation of CHOPB. However, a significant (P < 0.03) decrease in mean T, was observed only after two cycles of CHOPB. Both MRI methods produced high-resolution (0.1 x 0.1 x 1.0 mm(3)) maps of regional therapeutic response in the treated tumors based on local apparent diffusion coefficient and T-2. Only a specific region of the tumors (in 3 of the 5 tumors) corresponding to about one third of the turner volume exhibited a response-associate increase in ADC and decrease in T,. An adjacent region exhibited an increase in T-2, and no change in ADC. The rest of the tumor was indistinguishable from sham-treated controls by MRI criteria. The therapeutic response of the treated tumors detected by MRI was accompanied by changes in tumor cell density, proliferation and apoptosis revealed by histological studies performed upon completion of the longitudinal study. The mechanism producing the regional response of the tumor remains to be elucidated. Copyright (c) 2008 John Wiley & Sons, Ltd.
引用
收藏
页码:1021 / 1029
页数:9
相关论文
共 58 条
  • [1] Biexponential parameterization of diffusion and T2 relaxation decay curves in a rat muscle edema model:: Decay curve components and water compartments
    Ababneh, Z
    Beloeil, H
    Berde, CB
    Gambarota, G
    Maier, SE
    Mulkern, RV
    [J]. MAGNETIC RESONANCE IN MEDICINE, 2005, 54 (03) : 524 - 531
  • [2] Al-Katib AM, 1998, CLIN CANCER RES, V4, P1305
  • [3] *AM CANC SOC, 2006, CANC FACTS FIG 2006
  • [4] Predicting treatment response in non-Hodgkin's lymphoma from the pretreatment tumor content of phosphoethanolamine plus phosphocholine
    Arias-Mendoza, F
    Smith, MR
    Brown, TR
    [J]. ACADEMIC RADIOLOGY, 2004, 11 (04) : 368 - 376
  • [5] Barboriak Daniel P, 2003, Magn Reson Imaging Clin N Am, V11, P379, DOI 10.1016/S1064-9689(03)00065-5
  • [6] Detection of tumor response to radiation therapy by in vivo proton MR spectroscopy
    Bhujwalla, ZM
    Glickson, JD
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1996, 36 (03): : 635 - 639
  • [7] In vivo and ex vivo proton MR spectroscopy of primary and secondary melanoma
    Bourne, RM
    Stanwell, P
    Stretch, JR
    Scolyer, RA
    Thompson, JF
    Mountford, CE
    Lean, CL
    [J]. EUROPEAN JOURNAL OF RADIOLOGY, 2005, 53 (03) : 506 - 513
  • [8] BRAUNSCHWEIGER PG, 1990, CANCER RES, V50, P4709
  • [9] 17O-decoupled 1H spectroscopy and imaging with a surface coil:: STEAM decoupling
    Charagundla, SR
    Duvvuri, U
    Noyszewski, EA
    Dandora, R
    Stolpen, AH
    Leigh, JS
    Reddy, R
    [J]. JOURNAL OF MAGNETIC RESONANCE, 2000, 143 (01) : 39 - 44
  • [10] Charles-Edwards Elizabeth M, 2006, Cancer Imaging, V6, P135, DOI 10.1102/1470-7330.2006.0021