Direct access to novel chromeno-pyrimidine-N-oxides via tandem base catalyzed double nucleophilic addition/dehydration reaction

被引：9
作者：
Jalli, Venkata Prasad [1 ]
Jaggavarapu, Satyanarayana Reddy [1 ]
Kamalakaran, Anand Solomon [1 ]
Gangisetty, Sravan Kumar [1 ]
Nanubolu, Jagadeesh Babu [2 ]
Gaddamanugu, Gopikrishna [1 ]
机构：
[1] Sankar Fdn Res Inst, Dept Chem, Visakhapatnam 530047, Andhra Pradesh, India
[2] Indian Inst Chem Technol, Xray Crystallog Div, Hyderabad 500076, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 11期
关键词：
Pyrimidine-N-oxides; 4-Chloro-3-formylcoumarin; Carboximide oxime; Chromeno-pyrimidine-N-oxide; Tandem; MINOXIDIL SULFATE; DERIVATIVES; REARRANGEMENTS; MECHANISMS;
D O I：
10.1016/j.tetlet.2013.01.044
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile protocol for direct access to chromeno-pyrimidine-N-oxides is reported by the reaction of 4-chloro-3-formylcoumarin and aromatic carboximide oximes via tandem double nucleophilic addition and dehydration reactions. The one-pot reaction serves as an alternative protocol for achieving regioselective pyrimidine mono-N-oxide products as pure precipitates in good to excellent yields. The structure of the product was confirmed by X-ray analysis. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1491 / 1494
页数：4
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