共 89 条
Aiding and abetting cancer: mRNA export and the nuclear pore
被引:57
作者:

Culjkovic-Kraljacic, Biljana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montreal, IRIC, Dept Pathol & Cell Biol, Montreal, PQ H3T 1J4, Canada Univ Montreal, IRIC, Dept Pathol & Cell Biol, Montreal, PQ H3T 1J4, Canada

Borden, Katherine L. B.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montreal, IRIC, Dept Pathol & Cell Biol, Montreal, PQ H3T 1J4, Canada Univ Montreal, IRIC, Dept Pathol & Cell Biol, Montreal, PQ H3T 1J4, Canada
机构:
[1] Univ Montreal, IRIC, Dept Pathol & Cell Biol, Montreal, PQ H3T 1J4, Canada
基金:
美国国家卫生研究院;
关键词:
HEAT-SHOCK;
ONCOGENIC TRANSFORMATION;
GASTRIC-CARCINOMA;
NUCLEOPORIN NUP98;
GENE-REGULATION;
CLINICAL-TRIAL;
EIF4E;
EXPRESSION;
COMPLEX;
TRANSPORT;
D O I:
10.1016/j.tcb.2013.03.004
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
mRNA export is a critical step in gene expression. Export of transcripts can be modulated in response to cellular signaling or stress. Consistently, mRNA export is dysregulated in primary human specimens derived from many different forms of cancer. Aberrant expression of export factors can alter the export of specific transcripts encoding proteins involved in proliferation, survival, and oncogenesis. These specific factors, which are not used for bulk mRNA export, are obvious therapeutic targets. Indeed, given the emerging role of mRNA export in cancer, it is not surprising that efforts to target different aspects of this pathway have reached the clinical trial stage. Thus, like transcription and translation, mRNA export may also play a critical role in cancer genesis and maintenance.
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页码:328 / 335
页数:8
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