Aiding and abetting cancer: mRNA export and the nuclear pore

被引:57
作者
Culjkovic-Kraljacic, Biljana [1 ]
Borden, Katherine L. B. [1 ]
机构
[1] Univ Montreal, IRIC, Dept Pathol & Cell Biol, Montreal, PQ H3T 1J4, Canada
基金
美国国家卫生研究院;
关键词
HEAT-SHOCK; ONCOGENIC TRANSFORMATION; GASTRIC-CARCINOMA; NUCLEOPORIN NUP98; GENE-REGULATION; CLINICAL-TRIAL; EIF4E; EXPRESSION; COMPLEX; TRANSPORT;
D O I
10.1016/j.tcb.2013.03.004
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
mRNA export is a critical step in gene expression. Export of transcripts can be modulated in response to cellular signaling or stress. Consistently, mRNA export is dysregulated in primary human specimens derived from many different forms of cancer. Aberrant expression of export factors can alter the export of specific transcripts encoding proteins involved in proliferation, survival, and oncogenesis. These specific factors, which are not used for bulk mRNA export, are obvious therapeutic targets. Indeed, given the emerging role of mRNA export in cancer, it is not surprising that efforts to target different aspects of this pathway have reached the clinical trial stage. Thus, like transcription and translation, mRNA export may also play a critical role in cancer genesis and maintenance.
引用
收藏
页码:328 / 335
页数:8
相关论文
共 89 条
[1]   Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin [J].
Assouline, Sarit ;
Culjkovic, Biljana ;
Cocolakis, Eftihia ;
Rousseau, Caroline ;
Beslu, Nathalie ;
Amri, Abdellatif ;
Caplan, Stephen ;
Leber, Brian ;
Roy, Denis-Claude ;
Miller, Wilson H., Jr. ;
Borden, Katherine L. B. .
BLOOD, 2009, 114 (02) :257-260
[2]   Preserving the genome by regulating chromatin association with the nuclear envelope [J].
Bermejo, Rodrigo ;
Kumar, Amit ;
Foiani, Marco .
TRENDS IN CELL BIOLOGY, 2012, 22 (09) :465-473
[3]   Nup358/RanBP2 attaches to the nuclear pore complex via association with Nup88 and Nup214/CAN and plays a supporting role in CRM1-mediated nuclear protein export [J].
Bernad, R ;
van der Velde, H ;
Fornerod, M ;
Pickersgill, H .
MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (06) :2373-2384
[4]   Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis [J].
Boer, J ;
Bonten-Surtel, J ;
Grosveld, G .
MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (03) :1236-1247
[5]   Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond? [J].
Borden, Katherine L. B. ;
Culjkovic-Kraljacic, Biljana .
LEUKEMIA & LYMPHOMA, 2010, 51 (10) :1805-1815
[6]   Protein ligands to HuR modulate its interaction with target mRNAs in vivo [J].
Brennan, CM ;
Gallouzi, IE ;
Steitz, JA .
JOURNAL OF CELL BIOLOGY, 2000, 151 (01) :1-13
[7]   The role of nuclear pores in gene regulation, development and disease [J].
Capelson, Maya ;
Hetzer, Martin W. .
EMBO REPORTS, 2009, 10 (07) :697-705
[8]   The Mitogen-Activated Protein Kinase Slt2 Regulates Nuclear Retention of Non-Heat Shock mRNAs during Heat Shock-Induced Stress [J].
Carmody, Sean R. ;
Tran, Elizabeth J. ;
Apponi, Luciano H. ;
Corbett, Anita H. ;
Wente, Susan R. .
MOLECULAR AND CELLULAR BIOLOGY, 2010, 30 (21) :5168-5179
[9]   mRNA nuclear export at a glance [J].
Carmody, Sean R. ;
Wente, Susan R. .
JOURNAL OF CELL SCIENCE, 2009, 122 (12) :1933-1937
[10]   Nucleoporin Levels Regulate Cell Cycle Progression and Phase-Specific Gene Expression [J].
Chakraborty, Papia ;
Wang, Yaming ;
Wei, Jen-Hsuan ;
van Deursen, Jan ;
Yu, Hongtao ;
Malureanu, Liviu ;
Dasso, Mary ;
Forbes, Douglass J. ;
Levy, David E. ;
Seemann, Joachim ;
Fontoura, Beatriz M. A. .
DEVELOPMENTAL CELL, 2008, 15 (05) :657-667