Syntheses and evaluation of glucosyl aryl thiosemicarbazide and glucosyl thiosemicarbazone derivatives as antioxidant and anti-dyslipidemic agents

被引：58

作者：

Ghosh, Samir ^{[1
,2
]}

Misra, Anup Kumar ^{[1
,2
]}

Bhatia, Gitika ^{[3
]}

Khan, M. M. ^{[3
]}

Khanna, A. K. ^{[3
]}

机构：

[1] Bose Inst, Div Mol Med, Kolkata 700054, India

[2] Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

[3] Cent Drug Res Inst, Div Biochem, Lucknow 226001, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 02期

关键词：

Thiosemicarbazide; Thiosemicarbazone; Antidyslipidemic; Antioxidant; Cholesterol; LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; ATHEROSCLEROSIS; PATHOGENESIS; CHOLESTEROL; RADICALS; HDL;

D O I：

10.1016/j.bmcl.2008.11.070

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-per-O-acetyl-glucosyl arylthiosemicarbazide and thiosemicarbazone derivatives have been synthesized and evaluated for their in vivo anti-dyslipidemic and in vitro antioxidant activities. Among 16 compounds tested, 3 compounds showed potent anti-dyslipidemic activity and 6 compounds showed potent antioxidant and scavenger of oxygen free radicals activity. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：386 / 389

页数：4

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