Syntheses and evaluation of glucosyl aryl thiosemicarbazide and glucosyl thiosemicarbazone derivatives as antioxidant and anti-dyslipidemic agents

被引：58
|
作者：
Ghosh, Samir [1 ,2 ]
Misra, Anup Kumar [1 ,2 ]
Bhatia, Gitika [3 ]
Khan, M. M. [3 ]
Khanna, A. K. [3 ]
机构：
[1] Bose Inst, Div Mol Med, Kolkata 700054, India
[2] Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India
[3] Cent Drug Res Inst, Div Biochem, Lucknow 226001, Uttar Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 02期
关键词：
Thiosemicarbazide; Thiosemicarbazone; Antidyslipidemic; Antioxidant; Cholesterol; LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; ATHEROSCLEROSIS; PATHOGENESIS; CHOLESTEROL; RADICALS; HDL;
D O I：
10.1016/j.bmcl.2008.11.070
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of N-per-O-acetyl-glucosyl arylthiosemicarbazide and thiosemicarbazone derivatives have been synthesized and evaluated for their in vivo anti-dyslipidemic and in vitro antioxidant activities. Among 16 compounds tested, 3 compounds showed potent anti-dyslipidemic activity and 6 compounds showed potent antioxidant and scavenger of oxygen free radicals activity. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：386 / 389
页数：4
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