Heart Failure-Induced Cachexia

被引：20

作者：

Okoshi, Marina Politi ^{[1
]}

Romeiro, Fernando G. ^{[1
]}

Paiva, Sergio A. R. ^{[1
]}

Okoshi, Katashi ^{[1
]}

机构：

[1] UNESP, Fac Med Botucatu, Dept Clin Med, Botucatu, SP, Brazil

来源：

ARQUIVOS BRASILEIROS DE CARDIOLOGIA | 2013年 / 100卷 / 05期

关键词：

TUMOR-NECROSIS-FACTOR; LEFT-VENTRICULAR DYSFUNCTION; CHRONIC FOOD RESTRICTION; SKELETAL-MUSCLE ATROPHY; BODY-COMPOSITION; PROINFLAMMATORY CYTOKINES; EXERCISE CAPACITY; CARDIAC CACHEXIA; MAXIMAL EXERCISE; DOUBLE-BLIND;

D O I：

10.5935/abc.20130060

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure patients often develop cachexia, which is an independent factor for survival reduction. Cachexia can be diagnosed when there is loss of more than 6% of the body weight, in the absence of other diseases. Even though its pathophysiology has not yet been completely clarified, various factors seem to be involved, such as reduction in food consumption, gastrointestinal tract abnormalities, immunologic and neuro-hormonal activarion and changes in the relationship between anabolic and catabolic processes. Since there is not specific therapy for heart failure-induced cachexia, management is based on nutritional support, neuro-hormonal blockade, control of edema and anemia and exercise. Drugs with anabolic and immunomodulating properties are being evaluated and clinical and non-clinical trials.

引用

页码：476 / 482

页数：7

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