Versatile control of multiphase laminar flow for in-channel microfabrication

被引:21
作者
Gao, Yunxiang [1 ]
Chen, Liwei [1 ]
机构
[1] Ohio Univ, Dept Chem & Biochem, Clippinger Labs 136, Athens, OH 45701 USA
关键词
D O I
10.1039/b807468b
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We have improved the multiphase laminar flow based in-channel fabrication method to overcome diffusion-induced broadening. A sheathing phase with protecting molecules confines metal wire deposition and allows for flexible control of the location, width, and uniformity of deposited metal wires. Two-layered T-junctions are introduced to form vertically stacked multiphase laminar flow. Combining these techniques, we fabricate quadrupole silver electrodes on the four sidewalls of rectangular polydimethylsiloxane (PDMS) microchannels that are 3 cm in length.
引用
收藏
页码:1695 / 1699
页数:5
相关论文
共 27 条
[11]   A soft lithographic approach to fabricate patterned microfluidic channels [J].
Khademhosseini, A ;
Suh, KY ;
Jon, S ;
Eng, G ;
Yeh, J ;
Chen, GJ ;
Langer, R .
ANALYTICAL CHEMISTRY, 2004, 76 (13) :3675-3681
[12]   Hydrodynamic focusing on a silicon chip: Mixing nanoliters in microseconds [J].
Knight, JB ;
Vishwanath, A ;
Brody, JP ;
Austin, RH .
PHYSICAL REVIEW LETTERS, 1998, 80 (17) :3863-3866
[13]   A microfabricated device for subcellular organelle sorting [J].
Lu, H ;
Gaudet, S ;
Schmidt, MA ;
Jensen, KF .
ANALYTICAL CHEMISTRY, 2004, 76 (19) :5705-5712
[14]   Controlling electroosmotic flow in poly(dimethylsiloxane) separation channels by means of prepolymer additives [J].
Luo, Yiqi ;
Huang, Bo ;
Wu, Hongkai ;
Zare, Richard N. .
ANALYTICAL CHEMISTRY, 2006, 78 (13) :4588-4592
[15]   Poly(dimethylsiloxane) as a material for fabricating microfluidic devices [J].
McDonald, JC ;
Whitesides, GM .
ACCOUNTS OF CHEMICAL RESEARCH, 2002, 35 (07) :491-499
[16]   Lab-on-a-chip: applications in proteomics [J].
Mouradian, S .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (01) :51-56
[17]  
Ng JMK, 2002, ELECTROPHORESIS, V23, P3461, DOI 10.1002/1522-2683(200210)23:20<3461::AID-ELPS3461>3.0.CO
[18]  
2-8
[19]   Advances in polymerase chain reaction on microfluidic chips [J].
Roper, MG ;
Easley, CJ ;
Landers, JP .
ANALYTICAL CHEMISTRY, 2005, 77 (12) :3887-3893
[20]   Bioanalysis in structured microfluidic systems [J].
Ros, Alexandra ;
Hellmich, Wibke ;
Regtmeier, Jan ;
Duong, Thanh Tu ;
Anselmetti, Dario .
ELECTROPHORESIS, 2006, 27 (13) :2651-2658