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Chinese Acad Med Sci, Peking Union Med Coll, State Key Lab Common Mech Res Major Dis, Sch Basic Med,Haihe Lab Cell Ecosyst,Dept Cell Bio, Beijing 100005, Peoples R China Chinese Acad Med Sci, Peking Union Med Coll, State Key Lab Common Mech Res Major Dis, Sch Basic Med,Haihe Lab Cell Ecosyst,Dept Cell Bio, Beijing 100005, Peoples R China