Effects of Saiboku-to on dual-phase bronchoconstriction in asthmatic guinea pigs

被引:12
作者
Tohda, Y
Haraguchi, R
Kubo, H
Muraki, M
Fukuoka, M
Nakajima, S
机构
[1] Kinki Univ, Sch Med, Dept Internal Med 4, Osaka 589, Japan
[2] Kinki Univ, Inst Life Sci, Osaka, Japan
来源
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | 1999年 / 21卷 / 06期
关键词
Saiboku-to; asthma; eosinophils; Kampo medicine;
D O I
10.1358/mf.1999.21.6.541927
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In recent years, bronchial asthma has come to be regarded pathologically as a chronic inflammatory disease of the respiratory tract. Inhalational steroids and antiinflammatory drugs are recognized as being effective against bronchial asthma. In this study, the effects of Saiboku-to, a Chinese her bal (Kampo) formulation, were investigated on asthmatic guinea pigs sensitized to ovalbumin (OA). Following 7-day administration of Saiboku-to (500 mu g/kg), the late asthmatic response (LAR) to an antigen challenge was found to be inhibited. The number of eosinophils in fluid obtained by bronchoalveolar lavage (BAL) 4 h after antigen challenge was decreased while the infiltration of eosinophils and T-lymphocytes into the lung parenchyma was inhibited. These findings suggest that Saiboku-to has the potential to become a useful drug in the treatment of bronchial asthma. (C)1999 Prous Science. All rights reserved.
引用
收藏
页码:449 / 452
页数:4
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