Pneumococcal Meningitis during Antiviral Treatment with Interferon and Ribavirin in a Splenectomized Patient with Chronic Hepatitis C - Do Not Miss Vaccination before Starting Therapy

被引：3
作者：
Hadem, J. [1 ]
Cornberg, M.
Hauptmann, C. [2 ]
Suettmann, U. [3 ]
Manns, M. P.
Wedemeyer, H.
机构：
[1] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany
[2] Hosp Lehrte, Lehrte, Germany
[3] Outpatient Clin Lehrte, Lehrte, Germany
来源：
ZEITSCHRIFT FUR GASTROENTEROLOGIE | 2008年 / 46卷 / 09期
关键词：
Hepatitis C; bacterial meningitis; Pneumococcus; Interferon; Ribavirin; non-response; vaccination; splenectomy;
D O I：
10.1055/s-2008-1027149
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
We report on a 35-year-old man who developed pneumococcal meningitis while receiving antiviral therapy with interferon (consensus interferon, CIFN) and ribavirin for chronic hepatitis C. Antibiotic therapy was started four days after the onset of symptoms. Unfortunately, the patient developed a persisting right-sided cochlear hearing impairment. Antiviral therapy led to sustained viral response of hepatitis C. At the age of 14 years he had experienced a hemorrhagic shock after a traffic accident, received multiple blood transfusions and undergone a splenectomy. He had not received vaccination against Streptococcus pneumoniae. This case report reminds us that splenectomized patients without previous pneumococcal vaccination should receive such vaccination before immunomodulatory treatment.
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收藏
页码：880 / 882
页数：3
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