Psychoactive Substance Effect on Mental Health and Well-Being Focusing on Student-Aged Lithuanian Cohort of Sexual Minorities

Mental health refers to cognitive, behavioral, and emotional well-being. However, significant research gaps are still found in disclosing the disparities in mental health outcomes between heterosexual and sexual minority (SM) individuals during the period of 20-24 years of age. Therefore, the aim of this study was to assess the association between the prevalence of psychoactive substance use and the severity of anxiety or depressive symptoms, and well-being across SM and non-SM student-aged populations (N = 1330). This cross-sectional study was conducted in Lithuania over the period of fifteen months following the beginning of the COVID-19 pandemic. This study concentrated on the mental health symptomatology, well-being status, and the prevalence of the psychoactive substance use, which were measured by three screening instruments. In terms of negative well-being, mental health problems, and health-risk behaviors, it was found that the SMs were potentially more exposed than the non-SMs. The current study also revealed a significant impact of substance use (alcohol consumption, cigarette smoking) on the symptoms of anxiety (adjusted odds ratios (AOR) 1.6 (95% confidence interval (CI): 1.0-2.6), AOR 1.5 (95% CI: 1.0-2.2)), and negative well-being (AOR 1.7 (95% CI: 1.0-2.8), AOR 1.7 (95% CI: 1.1-2.5)) across the SM student-aged group. The association between the increased self-administration of cannabis and positive mental health outcomes appertained to milder anxiety symptoms amid SMs has been identified (AOR 0.5 (95% CI: 0.2-0.9)). Given that minority stressors could play an important part in mediating between the sexual orientation and negative outcomes of mental and behavioral health in student-aged populations, health strategies should focus on the development of effective substance abuse and drug prevention programs, both student-centered and SMs-centered, aimed to reduce health-risk behaviors in emerging adulthood.