Interaction of trivalent antimony with a CCHC zinc finger domain:: potential relevance to the mechanism of action of antimonial drugs

被引：36

作者：

Demicheli, Cynthia ^{[1
]}

Frezard, Frederic ^{[2
]}

Mangrum, John B. ^{[3
]}

Farrell, Nicholas P. ^{[3
]}

机构：

[1] Univ Fed Minas Gerais, Dept Quim, ICEX, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Fisol & Biofis, ICB, BR-31270901 Belo Horizonte, MG, Brazil

[3] Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 39期

关键词：

D O I：

10.1039/b809186b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sb III competes with Zn II for its binding to the CCHC zinc. nger domain of the NCp7 protein of HIV-1, indicating that zinc finger proteins may be targets for antimony-based drugs and thus responsible for their important pharmacological actions.

引用

页码：4828 / 4830

页数：3

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