共 49 条
- [42] Determination of Intrinsic Clearance and Fraction Unbound in Human Liver Microsomes and In Vitro-In Vivo Extrapolation of Human Hepatic Clearance for Marketed Central Nervous System Drugs (Dec, 10.1007/s13318-024-00931-2, 2024) EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2025, 50 (02) : 137 - 137
- [43] A new guidance for the prediction of hepatic clearance in the early drug discovery and development from the in vitro-to-in vivo extrapolation method and an approach for exploring whether an albumin-mediated hepatic uptake phenomenon could be present under in vivo conditions JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 110 (07) : 2841 - 2858
- [44] Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro–In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound European Journal of Drug Metabolism and Pharmacokinetics, 2017, 42 : 537 - 543
- [47] Uridine 5′-Diphospho-glucuronosyltransferase 1A3 (UGT1A3) Prediction of Hepatic Clearance of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Substrate Telmisartan by Glucuronidation Using In Vitro-In Vivo Extrapolation (IVIVE) EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2024, 49 (03) : 393 - 403
- [48] Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro - in vivo extrapolation of hepatic clearance EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 101 : 80 - 89