AN EVOLVING SEMI-PBPK APPROACH FOR THE IN VITRO-IN VIVO EXTRAPOLATION OF HEPATIC AND EXTRA-HEPATIC CLEARANCE OF TARGETED COVALENT INHIBITORS

被引:0
|
作者
Strelevitz, Timothy [1 ]
机构
[1] Pfizer Inc, New York, NY USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:51 / 51
页数:1
相关论文
共 49 条
  • [32] In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish - I. A review of methods, and strategies for incorporating intrinsic clearance estimates into chemical kinetic models
    Nichols, John W.
    Schultz, Irvin R.
    Fitzsimmons, Patrick N.
    AQUATIC TOXICOLOGY, 2006, 78 (01) : 74 - 90
  • [33] In Vitro-In Vivo Extrapolation of Hepatic Biotransformation Data for Fish. III. An In-depth Case Study with Pyrene
    Nichols, John W. W.
    Fitzsimmons, Patrick N. N.
    Hoffman, Alex D. D.
    Wong, Kameron
    ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2023, 42 (07) : 1501 - 1515
  • [34] In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish. II. Modeled effects on chemical bioaccumulation
    Nichols, John W.
    Fitzsimmons, Patrick N.
    Burkhard, Lawrence P.
    ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2007, 26 (06) : 1304 - 1319
  • [35] Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance
    De Bruyn, Tom
    Ufuk, Ayse
    Cantrill, Carina
    Kosa, Rachel E.
    Bi, Yi-an
    Niosi, Mark
    Modi, Sweta
    Rodrigues, A. David
    Tremaine, Larry M.
    Varma, Manthena V. S.
    Galetin, Aleksandra
    Houston, J. Brian
    DRUG METABOLISM AND DISPOSITION, 2018, 46 (07) : 989 - 1000
  • [36] Albumin-Mediated Uptake Improves Human Clearance Prediction for Hepatic Uptake Transporter Substrates Aiding a Mechanistic In Vitro-In Vivo Extrapolation (IVIVE) Strategy in Discovery Research
    Na Li
    Akshay Badrinarayanan
    Kazuya Ishida
    Xingwen Li
    John Roberts
    Shuai Wang
    Mike Hayashi
    Anshul Gupta
    The AAPS Journal, 23
  • [37] Albumin-Mediated Uptake Improves Human Clearance Prediction for Hepatic Uptake Transporter Substrates Aiding a Mechanistic In Vitro-In Vivo Extrapolation (IVIVE) Strategy in Discovery Research
    Li, Na
    Badrinarayanan, Akshay
    Ishida, Kazuya
    Li, Xingwen
    Roberts, John
    Wang, Shuai
    Hayashi, Mike
    Gupta, Anshul
    AAPS JOURNAL, 2020, 23 (01):
  • [38] Extrapolation of In Vivo Hepatic Clearance from In Vitro Uptake Clearance by Suspended Human Hepatocytes for Anionic Drugs with High Binding to Human Albumin: Improvement of In Vitro-to-In Vivo Extrapolation by Considering the "Albumin-Mediated" Hepatic Uptake Mechanism on the Basis of the "Facilitated-Dissociation Model"
    Kim, Soo-Jin
    Lee, Kyeong-Ryoon
    Miyauchi, Seiji
    Sugiyama, Yuichi
    DRUG METABOLISM AND DISPOSITION, 2019, 47 (02) : 94 - 103
  • [39] IMPACT OF ORGANIC SOLVENTS ON THE KINETICS OF (S)-WARFARIN AND MIDAZOLAM HYDROXYLATION TO IMPROVE INTERPRETATION AND ACCURACY OF IN VITRO-IN VIVO PREDICTIONS OF HEPATIC CLEARANCE
    Gonzalez-Perez, Vanessa
    Connolly, Elizabeth A.
    Bridges, Arlene S.
    Wienkers, Larry C.
    Paine, Mary F.
    DRUG METABOLISM REVIEWS, 2012, 44 : 53 - 53
  • [40] Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mechanistic Insights
    Poulin, Patrick
    Haddad, Sami
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 107 (07) : 1791 - 1797