Isotretinoin-induced skeletal hyperostosis

被引：4

作者：

Graf, Scott W. ^{[1
]}

Whittle, Samuel L. ^{[2
]}

机构：

[1] Royal Adelaide Hosp, Dept Gen Med, Adelaide, SA 5000, Australia

[2] Queen Elizabeth Hosp, Rheumatol Unit, Woodville South, SA, Australia

来源：

SPRINGERPLUS | 2014年 / 3卷

关键词：

LOW-DOSE ISOTRETINOIN; 13-CIS-RETINOIC ACID; LONG-TERM; THERAPY; TOXICITY;

D O I：

10.1186/2193-1801-3-698

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We describe a case of skeletal hyperostosis in a 29 year old man presenting with non-inflammatory back pain with a past history of isotretinoin therapy for acne. The development of skeletal hyperostosis, predominantly of the spine, has been reported in association with isotretinoin use and has a radiographic picture similar to diffuse idiopathic skeletal hyperostosis. The prevalence and severity of this condition appears to correlate with duration of therapy. Isotretinoin is a well-established treatment for severe acne. It is important for the rheumatologist be aware of this phenomenon when assessing young patients with musculoskeletal symptoms and evidence of radiological abnormalities.

引用

页数：4

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