Influence of aspirin on platelet count and volume in humans

被引：60

作者：

Erhart, S

Beer, JH

Reinhart, WH ^{[1
]}

机构：

[1] Kantonsspital, CH-7000 Chur, Switzerland

[2] Univ Bern, Dept Internal Med, CH-3012 Bern, Switzerland

来源：

ACTA HAEMATOLOGICA | 1999年 / 101卷 / 03期

关键词：

aspirin; glycocalicin; platelets; thrombopoietin;

D O I：

10.1159/000040940

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelet volume and total platelet mass are parameters of platelet activity and have become a prognostic factor in coronary heart disease. We have studied the influence of aspirin on platelet count, volume and total platelet mass in vitro and in a randomized double-blind, placebo-controlled study in 20 healthy young male volunteers in vivo. Aspirin had no influence in vitro on either platelet count, volume or mass. Repeated blood sampling during a 7-day treatment with 250 mg aspirin daily showed an increased platelet count (7.3% on day 1, 3.0% on day 2, 6.8% on day 4 and 9.3% on day 7; p < 0.01) and total platelet mass (7.2, 5.0, 8.6 and 11.5% on days 1, 2, 4 and 7, respectively, p < 0.01), Aspirin treatment without repeated blood withdrawal had no effect. These data indicate that aspirin may affect the circulating platelet mass under certain conditions.

引用

页码：140 / 144

页数：5

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