Neuroprotection is unlikely to be effective in humans using current trial designs: An opposing view

被引：29
作者：
Lees, KR [1 ]
机构：
[1] Univ Glasgow, Western Infirm, Univ Dept Med & Therapeut, Glasgow G11 6NT, Lanark, Scotland
来源：
STROKE | 2002年 / 33卷 / 01期
关键词：
clinical trials; neuroprotection; stroke assessment;
D O I：
10.1161/str.33.1.308
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
引用
收藏
页码：308 / 309
页数：2
相关论文
共 10 条
  • [1] Fiction and regional culture in Senegal: From the origins to 1992
    Dieng, B
    [J]. RESEARCH IN AFRICAN LITERATURES, 1999, 30 (02) : 234 - 237
  • [2] Recommendations for standards regarding preclinical neuroprotective and restorative drug development
    Feinklestein, SP
    Fisher, M
    Furland, AJ
    Goldstein, LB
    Gorelick, PB
    Kaste, M
    Lees, KR
    Traystman, RJ
    Albers, GW
    Anwer, UE
    Ashwood, T
    Barone, FC
    Basta, SL
    Bogousslavsky, J
    Buchan, AM
    Cady, WJ
    Chan, PH
    Clemens, JA
    Cox, BF
    Craddock, RE
    Cramer, SC
    del Zoppo, GJ
    Dielrich, WD
    Elliott, P
    Faden, AI
    Feuerstein, GZ
    Ginsberg, MD
    Gold, M
    Greene, WL
    Hall, ED
    Hsu, CY
    Hunter, AJ
    Lai, M
    Lesko, LM
    Levy, DE
    Li, FH
    Locke, KW
    Lodge, D
    Lowe, D
    Marcoux, FW
    McCulloch, J
    McDermott, J
    Meibach, R
    Messersmith, EK
    Moseley, M
    Moskowitz, MA
    Mueller, AL
    Munro, F
    Nudo, RJ
    Oeda, J
    [J]. STROKE, 1999, 30 (12) : 2752 - 2758
  • [3] Kieser M, 1999, BIOMETRICAL J, V41, P261, DOI 10.1002/(SICI)1521-4036(199906)41:3<261::AID-BIMJ261>3.3.CO
  • [4] 2-L
  • [5] Neuroprotection
    Lees, KR
    [J]. BRITISH MEDICAL BULLETIN, 2000, 56 (02) : 401 - 412
  • [6] Glycine antagonist (GV150526) in acute stroke: A multicentre, double-blind placebo-controlled phase II trial
    Lees, KR
    Lavelle, JF
    Cunha, L
    Diener, HC
    Sanders, EACM
    Tack, P
    Wester, P
    [J]. CEREBROVASCULAR DISEASES, 2001, 11 (01) : 20 - 29
  • [7] Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial
    Lees, KR
    Asplund, K
    Carolei, A
    Davis, SM
    Diener, HC
    Kaste, M
    Orgogozo, JM
    Whitehead, J
    [J]. LANCET, 2000, 355 (9219) : 1949 - 1954
  • [8] LEES KR, 2001, CEREBROVASC DIS, P430
  • [9] Glycine antagonist in neuroprotection for patients with acute stroke - GAIN Americas: A randomized controlled trial
    Sacco, RL
    DeRosa, JT
    Haley, EC
    Levin, B
    Ordronneau, P
    Phillips, SJ
    Rundek, T
    Snipes, RG
    Thompson, JLP
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (13): : 1719 - 1728
  • [10] WEIR CJ, 1998, CEREBROVASC DIS, V8, P32
1