Ruthenium(II)-Catalyzed Synthesis of Hydroxylated Arenes with Ester as an Effective Directing Group

被引：136
作者：
Yang, Yiqing
Lin, Yun
Rao, Yu [1 ]
机构：
[1] Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, Beijing 100084, Peoples R China
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 11期
基金：
中国国家自然科学基金;
关键词：
C-H BOND; COPPER-CATALYZED ARYLATION; OXIDATIVE FUNCTIONALIZATION; COUPLING REACTION; PHOSPHINE OXIDES; PALLADIUM; PHENOL; ARYL; ACTIVATION; BENZENE;
D O I：
10.1021/ol301104n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unprecedented Ru(II) catalyzed ortho-hydroxylation has been developed for the facile synthesis of a variety of multifunctionalized arenes from easily accessible ethyl benzoates with ester as an efficient directing group. Both the TFA/TFAA cosolvent system and oxidants serve as the critical success factors in this transformation. The reaction demonstrates excellent reactivity, good functional group tolerance, and high yields.
引用
收藏
页码：2874 / 2877
页数：4
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