Utility of cyclodextrins in the formulation of genistein Part 1. Preparation and physicochemical properties of genistein complexes with native cyclodextrins

被引：38

作者：

Daruhazi, Agnes Emma ^{[1
]}

Szente, Lajos ^{[2
]}

Balogh, Balazs ^{[3
]}

Matyus, Peter ^{[3
]}

Beni, Szabolcs ^{[4
]}

Takacs, Maria ^{[4
]}

Gergely, Andras ^{[4
]}

Horvath, Peter ^{[4
]}

Szoke, Eva ^{[1
]}

Lemberkovics, Eva ^{[1
]}

机构：

[1] Semmelweis Univ, Dept Pharmacognosy, H-1085 Budapest, Hungary

[2] CycloLab Ltd, H-1097 Budapest, Hungary

[3] Semmelweis Univ, Dept Organ Chem, H-1092 Budapest, Hungary

[4] Semmelweis Univ, Dept Pharmaceut Chem, H-1092 Budapest, Hungary

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2008年 / 48卷 / 03期

关键词：

Ononis; Genistein; Solubility; Parent cyclodextrins; Circular dichroism; ROESY;

D O I：

10.1016/j.jpba.2008.06.007

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Isoflavones are suitable guest molecules for inclusion complex formation with cyclodextrins (CDs). The molecular encapsulation with CDs results in a solid, molecularly dispersed form and in a significantly improved aqueous solubility of isoflavones. Genistein, a key isoflavone constituent of Ononidis spinosae radix was found to form a supramolecular, non-covalent inclusion complex with both beta-cyclodextrin (beta-CD) and gamma-cyclodextrin (gamma-CD), while it did not form a stable complex with alpha-CD. The guest genistein was found to spatially located in the less polar cavity of cyclodextrin. The isolated binary genistein/CD complexes appeared novel crystalline lattices. The in vitro dissolution of genistein entrapped into both beta- and gamma-CD, significantly surpassed that of the plain isoflavone. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：636 / 640

页数：5

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