Fracture healing in SD rats' bioactivities of cucumber seed polysaccharides

被引：0
|
作者：
Zhang, Zhihong [1 ]
Zeng, Yuanning [2 ]
Peng, Donghui [1 ]
Xing, Na [3 ]
Bai, Haodong [1 ]
Li, Yuxin [1 ]
Cui, Na [1 ]
Su, Huilin [2 ]
Qiao, Tingting [2 ]
Shi, Congjing [2 ]
Kuang, Haixue [1 ,4 ]
Wang, Qiuhong [1 ,2 ]
机构：
[1] Heilongjiang Univ Chinese Med, Dept Chinese Med Proc, Key Lab Chinese Mat Med, Minist Educ, Harbin, Peoples R China
[2] Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Dept Chinese Med Proc, Guangzhou, Peoples R China
[3] Zhongke Zhongshan Inst Drug Innovat, Zhongshan Inst Drug Discovery, Zhongshan, Peoples R China
[4] Heilongjiang Univ Chinese Med, Key Lab Chinese Mat Med, Minist Educ, Harbin 150040, Peoples R China
来源：
PHARMACOGNOSY MAGAZINE | 2022年 / 18卷 / 79期
基金：
中国国家自然科学基金;
关键词：
Cucumber seeds; extraction of polysaccharides; fracture healing; polysaccharides; SD rats; ANTIOXIDANT; EXTRACTION;
D O I：
10.4103/pm.pm_14_22
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Aim/Background: We investigated the composition and structure of intracellular polysaccharides in cucumber seeds (CSs) and their effect on Sprague-Dawley (SD) rats and potential activity for fracture healing. Materials and Methods: Polysaccharides are its main water-soluble active ingredient. The SD rat tibia fracture model was established by surgical method, and the healing effect of cucumber seed polysaccharides (CSPs) on SD rat tibia fracture was preliminarily explored. Through histopathological observation, determination of rat serum indicators alkaline phosphatase (AKP), acid phosphatase (ACP), BGP, X-ray imaging observation, and micro-Computed Tomography (CT) imaging observation at different periods. Results and Conclusion: The results showed that CSP enhanced the activity of osteoblasts, increased the metabolic rate of osteoclasts, increased the secretion of AKP, BGP, and ACP, shortened the fracture healing time of SD rats and effectively promoted the healing of tibial fractures in SD rats.
引用
收藏
页码：738 / 745
页数：8
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