New Azaphilones and Chlorinated Phenolic Glycosides from Chaetomium elatum with Caspase-3 Inhibitory Activity

被引：32

作者：

Chen, Guo-Dong ^{[1
,5
]}

Li, Yan-Jun ^{[1
]}

Gao, Hao ^{[1
]}

Chen, Ying ^{[1
]}

Li, Xiao-Xia ^{[1
]}

Li, Jia ^{[2
,3
]}

Guo, Liang-Dong ^{[4
]}

Cen, Ying-Zhou ^{[5
]}

Yao, Xin-Sheng ^{[1
]}

机构：

[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China

[2] Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai, Peoples R China

[3] Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China

[4] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing, Peoples R China

[5] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China

来源：

PLANTA MEDICA | 2012年 / 78卷 / 15期

基金：

中国博士后科学基金;

关键词：

Chaetomium elatum; Chaetomiaceae; azaphilones; chlorinated phenolic glycosides; caspase-3; inhibitors; APOPTOSIS; GLOBOSUM;

D O I：

10.1055/s-0032-1315211

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new azaphilones, chaetomugilin S (1), 7,5'-bis-epi-chaetoviridin A (2), and 7-epi-chaetoviridin E (3), and two new chlorinated phenolic glycosides, globosumoside A (4) and globosumoside B (5), were isolated from the crude extract of the fungal strain Chaetomium elatum No. 89-1-3-1. Their structures were determined by detailed NMR and MS spectroscopic analyses. The absolute configurations of C-7 in chaetomugilin S (1), 7,5'-bis-epi-chaetoviridin A (2), and 7-epi-chaetoviridin E (3) were assigned by CD experiments, and the absolute configurations of 1 and 2 were established by X-ray crystallography. Compounds 1-3 are the first examples of 7R-configurated azaphilones with a chlorinated isochromen from Chaetomium spp. In addition, compounds 1-3 showed inhibitory activity in the cysteine aspartyl-specific protease-3 (caspase-3) enzymatic assay, with IC50 values of 20.6, 10.9, and 7.9 mu M, respectively.

引用

页码：1683 / 1689

页数：7

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