Synthesis and anti-inflammatory activity of 1-acetyl/propanoyl-5-aryl-3-(4-morpholinophenyl)-4,5-dihydro-1H-pyrazole derivatives

被引：9
|
作者：
Khalil, Omneya M. [1 ]
机构：
[1] Cairo Univ, Dept Organ Chem, Fac Pharm, Cairo 11562, Egypt
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 10期
关键词：
Synthesis; Pyrazolines; Anti-inflammatory activity; PYRAZOLINE DERIVATIVES; ANTIMICROBIAL EVALUATION; SCHIFF-BASES; AGENTS;
D O I：
10.1007/s00044-011-9862-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel pyrazoline derivatives containing 4-morpholinophenyl moiety were synthesized to investigate their potential anti-inflammatory activity. The chemical structures of the compounds were elucidated by spectral data and element analyses. The test compounds in the series exhibited different levels of anti-inflammatory activities when compared with reference drug indomethacin.
引用
收藏
页码：3240 / 3245
页数：6
相关论文
共 50 条
  • [41] Microwave-assisted green synthesis of 4,5-dihydro-1H-pyrazole-1-carbothioamides in water
    Farmani, Hamid Reza
    Mosslemin, Mohammad Hossein
    Sadeghi, Bahareh
    MOLECULAR DIVERSITY, 2018, 22 (03) : 743 - 749
  • [42] 3-(4-Chlorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
    Fun, Hoong-Kun
    Suwunwong, Thitipone
    Chantrapromma, Suchada
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2012, 68 : O259 - U1464
  • [43] MICROWAVE-ASSISTED SYNTHESIS OF 3-(2-BENZOYL-6-HYDROXY-3-METHYL BENZO [b] FURAN-5-YL)-5-(3-ARYL-1-PHENYL-1H-4-PYRAZOLYL)-4,5-DIHYDRO-1H-1-PYRAZOLE CARBOTHIOAMIDES AND THEIR ANTIMICROBIAL ACTIVITY
    Sarasija, M.
    Sudershan, K.
    Ashok, D.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2014, 23 (03) : 305 - 310
  • [44] Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1-Carboxymethyl-3-PyrroliN-2-Ones
    Pastukhova, E. V.
    Chashchina, S. V.
    Buldakova, E. A.
    Gein, V. L.
    Mokrushin, I. G.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2023, 57 (02) : 204 - 208
  • [45] 5-(4-Methoxyphenyl)-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
    Nonthason, Phonpawee
    Suwunwong, Thitipone
    Chantrapromma, Suchada
    Fun, Hoong-Kun
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O3501 - U1122
  • [46] Anti-Inflammatory Activity of 5-Aryl-4-Hetaroyl-3-Hydroxy-1-Hydroxyalkyl-3-Pyrrolin-2-Ones
    Gein, O. N.
    Mazunina, I. M.
    Gein, V. S.
    Rubtsova, D. D.
    Gein, V. L.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2024, 58 (08) : 1263 - 1266
  • [47] Effects of 1,3,5-triphenyl-4,5-dihydro-1H-pyrazole derivatives on cell-cycle and apoptosis in human acute leukemia cell lines
    Bubniak, Lorena dos Santos
    Gaspar, Pamela Cristina
    Rabello de Moraes, Ana Carolina
    Bigolin, Alisson
    de Souza, Rubia Karine
    Buzzi, Fatima Campos
    Correa, Rogerio
    Cechinel Filho, Valdir
    Bretanha, Lizandra Czermainski
    Micke, Gustavo Amadeu
    Nunes, Ricardo Jose
    Santos-Silva, Maria Claudia
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2017, 95 (05) : 548 - 563
  • [48] Discovery and evaluation of novel synthetic 5-alkyl-4-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoxaline-1-carbox-amide derivatives as anti-inflammatory agents
    Shen, Qing-Kun
    Gong, Guo-Hua
    Li, Gao-
    Jin, Mei-
    Cao, Li-Hua
    Quan, Zhe-Shan
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, 35 (01) : 85 - 95
  • [49] Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1-Carboxymethyl-3-PyrroliN-2-Ones
    E. V. Pastukhova
    S. V. Chashchina
    E. A. Buldakova
    V. L. Gein
    I. G. Mokrushin
    Pharmaceutical Chemistry Journal, 2023, 57 (2) : 204 - 208
  • [50] Synthesis and Analgesic and Anti-Inflammatory Activity of 5-Aryl-4-(4-Halobenzoyl)-3-Hydroxy-1-Carboxymethyl-3-Pyrrolin-2-Ones
    Pastukhova, E. V.
    Chashchina, S. V.
    Buldakova, E. A.
    Gein, V. L.
    Mokrushin, I. G.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2023,
12345