Synthesis and anti-inflammatory activity of 1-acetyl/propanoyl-5-aryl-3-(4-morpholinophenyl)-4,5-dihydro-1H-pyrazole derivatives

被引：9
|
作者：
Khalil, Omneya M. [1 ]
机构：
[1] Cairo Univ, Dept Organ Chem, Fac Pharm, Cairo 11562, Egypt
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 10期
关键词：
Synthesis; Pyrazolines; Anti-inflammatory activity; PYRAZOLINE DERIVATIVES; ANTIMICROBIAL EVALUATION; SCHIFF-BASES; AGENTS;
D O I：
10.1007/s00044-011-9862-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel pyrazoline derivatives containing 4-morpholinophenyl moiety were synthesized to investigate their potential anti-inflammatory activity. The chemical structures of the compounds were elucidated by spectral data and element analyses. The test compounds in the series exhibited different levels of anti-inflammatory activities when compared with reference drug indomethacin.
引用
收藏
页码：3240 / 3245
页数：6
相关论文
共 50 条
  • [1] Synthesis and anti-inflammatory activity of 1-acetyl/propanoyl-5-aryl-3-(4-morpholinophenyl)-4,5-dihydro-1H-pyrazole derivatives
    Omneya M. Khalil
    Medicinal Chemistry Research, 2012, 21 : 3240 - 3245
  • [2] 4,5-Dihydro-1H-pyrazole: an indispensable scaffold
    Alex, Jimi Marin
    Kumar, Raj
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2014, 29 (03) : 427 - 442
  • [3] Synthesis and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing an aminosulphonyl pharmacophore
    Abdellatif, Khaled R. A.
    Abdelgawad, Mohamed A.
    Elshemy, Heba A. H.
    Alsayed, Shahinda S. R.
    Kamel, Gehan
    ARCHIVES OF PHARMACAL RESEARCH, 2015, 38 (11) : 1932 - 1942
  • [4] Synthesis, and antibacterial activity of novel 4,5-dihydro-1H-pyrazole derivatives as DNA gyrase inhibitors
    Liu, Jia-Jia
    Sun, Juan
    Fang, Yun-Bin
    Yang, Yong-An
    Jiao, Rui-Hua
    Zhu, Hai-Liang
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, 12 (06) : 998 - 1008
  • [5] Crystal structure of 1-acetyl-3-(4-methylphenyl)-5-phenyl-4,5-dihydro-1H-pyrazole
    Bulbul, H.
    Tinmaz, F.
    Dege, N.
    Ilhan, I. Ozer
    Saripinar, E.
    CRYSTALLOGRAPHY REPORTS, 2014, 59 (07) : 1071 - 1073
  • [6] Crystal structure of 1-acetyl-3-(4-methylphenyl)-5-phenyl-4,5-dihydro-1H-pyrazole
    H. Bülbül
    F. Tinmaz
    N. Dege
    İ. Özer İlhan
    E. Sarıpınar
    Crystallography Reports, 2014, 59 : 1071 - 1073
  • [7] Synthesis, cyclooxygenase inhibition and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing methanesulphonyl pharmacophore
    Abdellatif, Khaled R. A.
    Elsaady, Mohammed T.
    Abdel-Aziz, Salah A.
    Abusabaa, Ahmed H. A.
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2016, 31 (06) : 1545 - 1555
  • [8] Synthesis, crystal structures and DFT studies of 1-[2-(5-methyl-2-benzoxazolinone-3-yl)acetyl]-3-phenyl-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole and 1-[2-(5-chloro-2-benzoxazolinone-3-yl)acetyl]-3-phenyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole
    Sahin, Zarife Sibel
    Salgin-Goksen, Umut
    Gokhan-Kelekci, Nesrin
    Isik, Samil
    JOURNAL OF MOLECULAR STRUCTURE, 2011, 1006 (1-3) : 147 - 158
  • [9] The synthesis and antitubercular activity of 4,5-dihydro-1H-pyrazole derivatives with a basic epoxybenzo[7,8]oxocine framework
    Stalinskaya, Alena L.
    Dengis, Natalia A.
    Vlasenko, Vasily S.
    Kulakov, Ivan V.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2024, 60 (1-2) : 41 - 47
  • [10] Synthesis of some new 1-acyl-5-aryl-3-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazole
    Dong, Heng-Shan
    Wang, Yan-Fei
    Shen, Guo-Liang
    Quan, Bin
    Dong, Wang-Jun
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2012, 49 (01) : 149 - 153
12345