Purpose: We performed this study to determine the association between serum 25-hydroxyvitamin D [25(OH) D] level and myopia in adults. Methods: A total of 25,199 subjects aged >= 20 years were included from the National Health and Nutrition Examination Survey 2008-2012. Blood 25(OH)D levels were evaluated from blood samples. Refractive error was measured without cycloplegia. Myopia and high myopia were defined as >=-0.50 diopters (D) and >=-6.0 D, respectively. Other covariates such as education, physical activity, and economic status were obtained from interviews. Results: Linear regression analysis showed that as 25(OH) D level increased by 1 ng/mL, myopic refractive error significantly decreased by 0.01 D (P < 0.001) after adjusting for potential confounders including sex, age, height, education level, economic status, physical activity, and sunlight exposure time. The odds ratios for myopia was 0.75 (95% Confidence interval [CI]; 0.67-0.84, P < 0.001) in the highest 25(OH) D quintile compared to the lowest quintile. The odds ratios for high myopia was 0.63 (95% CI; 0.47-0.85, P < 0.001) in the highest 25(OH)D quintile compared to the lowest quintile. Conclusion: Serum 25(OH)D level was inversely associated with myopia in Korean adults.
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Kyung Hee Univ, Grad Sch East West Med Sci, Dept Med Nutr, 1732 Deogyeong Daero, Yongin 17104, Gyeonggi, South KoreaKyung Hee Univ, Grad Sch East West Med Sci, Dept Med Nutr, 1732 Deogyeong Daero, Yongin 17104, Gyeonggi, South Korea
Kim, Dasom
Kim, Jihye
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Kyung Hee Univ, Grad Sch East West Med Sci, Dept Med Nutr, 1732 Deogyeong Daero, Yongin 17104, Gyeonggi, South KoreaKyung Hee Univ, Grad Sch East West Med Sci, Dept Med Nutr, 1732 Deogyeong Daero, Yongin 17104, Gyeonggi, South Korea
机构:
Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, Gyeonggi Do, South KoreaSeoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, Gyeonggi Do, South Korea
Lee, Sung Woo
Kim, Myounghee
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Eulji Univ, Coll Hlth Sci, Dept Dent Hyg, Songnam, Gyeonggi Do, South KoreaSeoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, Gyeonggi Do, South Korea
Kim, Myounghee
Kim, Ho
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Seoul Natl Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Seoul 110744, South KoreaSeoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, Gyeonggi Do, South Korea
Kim, Ho
Han, Seung Seok
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Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South KoreaSeoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, Gyeonggi Do, South Korea
Han, Seung Seok
Lee, Hajeong
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Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South KoreaSeoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, Gyeonggi Do, South Korea
Lee, Hajeong
Lee, Jung Pyo
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Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Seoul 110744, South KoreaSeoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, Gyeonggi Do, South Korea
Lee, Jung Pyo
Kim, Dong Ki
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Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South KoreaSeoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, Gyeonggi Do, South Korea
Kim, Dong Ki
Lim, Chun Soo
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Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Seoul 110744, South KoreaSeoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, Gyeonggi Do, South Korea
Lim, Chun Soo
Kim, Yon Su
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Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South KoreaSeoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, Gyeonggi Do, South Korea
Kim, Yon Su
Park, Ae Kyung
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Suncheon Natl Univ, Coll Pharm, Sunchon, Junranam Do, South KoreaSeoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, Gyeonggi Do, South Korea
Park, Ae Kyung
Joo, Kwon Wook
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Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South KoreaSeoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, Gyeonggi Do, South Korea
机构:
Univ Tasmania, Menzies Res Inst Tasmania, Hobart, Tas 7000, Australia
Shanghai Univ Tradit Chinese Med, Res Inst Orthoped, Shuguang Hosp, Shanghai, Peoples R ChinaUniv Tasmania, Menzies Res Inst Tasmania, Hobart, Tas 7000, Australia
Cao, Yuelong
Winzenberg, Tania
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Univ Tasmania, Menzies Res Inst Tasmania, Hobart, Tas 7000, AustraliaUniv Tasmania, Menzies Res Inst Tasmania, Hobart, Tas 7000, Australia
Winzenberg, Tania
Nguo, Kay
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Univ Tasmania, Menzies Res Inst Tasmania, Hobart, Tas 7000, AustraliaUniv Tasmania, Menzies Res Inst Tasmania, Hobart, Tas 7000, Australia
Nguo, Kay
Lin, Jianhao
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Peking Univ, Inst Bone & Joint, Peoples Hosp, Beijing, Peoples R ChinaUniv Tasmania, Menzies Res Inst Tasmania, Hobart, Tas 7000, Australia
Lin, Jianhao
Jones, Graeme
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Univ Tasmania, Menzies Res Inst Tasmania, Hobart, Tas 7000, AustraliaUniv Tasmania, Menzies Res Inst Tasmania, Hobart, Tas 7000, Australia
Jones, Graeme
Ding, Changhai
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Univ Tasmania, Menzies Res Inst Tasmania, Hobart, Tas 7000, Australia
Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, AustraliaUniv Tasmania, Menzies Res Inst Tasmania, Hobart, Tas 7000, Australia
机构:
Tianjin Med Univ, Dept Ophthalmol, Gen Hosp, Tianjin, Peoples R China
Tianjin Childrens Hosp, Dept Ophthalmol, Tianjin, Peoples R ChinaTianjin Med Univ, Dept Ophthalmol, Gen Hosp, Tianjin, Peoples R China
Wang, Huan
Wei, RuiHua
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Tianjin Med Univ, eye Inst, Eye Hosp, Tianjin, Peoples R China
Tianjin Med Univ, Sch Optometry, Eye Hosp, Tianjin, Peoples R ChinaTianjin Med Univ, Dept Ophthalmol, Gen Hosp, Tianjin, Peoples R China
Wei, RuiHua
Yan, Hua
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Tianjin Med Univ, Dept Ophthalmol, Gen Hosp, Tianjin, Peoples R China
Tianjin Med Univ, Basic Med Res Ctr, Lab Mol Ophthalmol, Tianjin, Peoples R China
Nankai Univ Tianjin, Sch Med, Tianjin, Peoples R ChinaTianjin Med Univ, Dept Ophthalmol, Gen Hosp, Tianjin, Peoples R China