The Importance of Cellular Senescence in Frailty and Cardiovascular Diseases

被引：12

作者：

Boccardi, Virginia ^{[1
]}

Mecocci, Patrizia ^{[1
]}

机构：

[1] Univ Perugia, Santa Maria della Misericordia Hosp, Dept Med, Sect Gerontol & Geriatr, Piazzale Gambuli 1, I-06132 Perugia, Italy

来源：

FRAILTY AND CARDIOVASCULAR DISEASES: RESEARCH INTO AN ELDERLY POPULATION | 2020年 / 1216卷

关键词：

Aging; Cardiovascular; Comorbidities; Frailty; Inflammation; Senescence; OLDER PERSONS; DYSFUNCTION; COMMUNITY; TELOMERE; CELLS; ATHEROSCLEROSIS; INFLAMMATION; ASSOCIATION; APOPTOSIS; ARTERIAL;

D O I：

10.1007/978-3-030-33330-0_9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Frailty is a complex clinical syndrome, progressively described in the last thirty years, resulting from multiple impairments across many organs and systems and characterized by a reduction in physiological reserves and increased vulnerability to stressors, as well. Cardiovascular diseases (CVDs) are a common health problem in very old populations. Age-related changes occur throughout the body and in all organs, including the cardiovascular system. Cellular senescence links age-related CVDs and frailty by many mechanisms of particular interest in the aging biology and geriatric syndromes. Cellular senescence may represent the pivotal factor with its senescence-associated secretory phenotype (SASP) leading to systemic inflammation. In this context, SASP may represent the key element in the association between aging, frailty and the development of age-related CVDs.

引用

页码：79 / 86

页数：8

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