The Importance of Cellular Senescence in Frailty and Cardiovascular Diseases

被引：12
作者：
Boccardi, Virginia [1 ]
Mecocci, Patrizia [1 ]
机构：
[1] Univ Perugia, Santa Maria della Misericordia Hosp, Dept Med, Sect Gerontol & Geriatr, Piazzale Gambuli 1, I-06132 Perugia, Italy
来源：
FRAILTY AND CARDIOVASCULAR DISEASES: RESEARCH INTO AN ELDERLY POPULATION | 2020年 / 1216卷
关键词：
Aging; Cardiovascular; Comorbidities; Frailty; Inflammation; Senescence; OLDER PERSONS; DYSFUNCTION; COMMUNITY; TELOMERE; CELLS; ATHEROSCLEROSIS; INFLAMMATION; ASSOCIATION; APOPTOSIS; ARTERIAL;
D O I：
10.1007/978-3-030-33330-0_9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Frailty is a complex clinical syndrome, progressively described in the last thirty years, resulting from multiple impairments across many organs and systems and characterized by a reduction in physiological reserves and increased vulnerability to stressors, as well. Cardiovascular diseases (CVDs) are a common health problem in very old populations. Age-related changes occur throughout the body and in all organs, including the cardiovascular system. Cellular senescence links age-related CVDs and frailty by many mechanisms of particular interest in the aging biology and geriatric syndromes. Cellular senescence may represent the pivotal factor with its senescence-associated secretory phenotype (SASP) leading to systemic inflammation. In this context, SASP may represent the key element in the association between aging, frailty and the development of age-related CVDs.
引用
收藏
页码：79 / 86
页数：8
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