Nanotechnology Approaches to Improving Cancer Immunotherapy

被引：31

作者：

Hagan, C. Tilden ^{[1
,2
,3
]}

Medik, Yusra B. ^{[1
,2
]}

Wang, Andrew Z. ^{[1
,2
]}

机构：

[1] Univ North Carolina Chapel Hill, Carolina Ctr Canc Nanotechnol Excellence, Lab Nano & Translat Med, Lineberger Comprehens Canc Ctr,Carolina Inst Nano, Chapel Hill, NC 27599 USA

[2] Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Dept Radiat Oncol, Chapel Hill, NC 27599 USA

[3] Univ North Carolina Chapel Hill, UNC NCSU Joint Dept Biomed Engn, Chapel Hill, NC USA

来源：

CANCER NANOTECHNOLOGY-BOOK | 2018年 / 139卷

关键词：

DENDRITIC CELLS; TARGETED DELIVERY; IMMUNE-RESPONSE; ANTITUMOR IMMUNITY; RNA DELIVERY; NANOPARTICLES; VACCINES; SYSTEM; VACCINATION; NANOVACCINE;

D O I：

10.1016/bs.acr.2018.05.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer immunotherapy is a powerful, growing treatment approach to cancer that can be combined with chemotherapy, radiotherapy, and oncosurgery. Modulating the immune system to enhance anticancer response by several strategies has yielded improved cancer survival. Despite this progress, the success rate for immunotherapy has been below expectations due to unpredictable efficacy and off-target side effects from systemic dosing. Nanotechnology offers numerous different materials and targeting properties to overcome many of these challenges in immunotherapy. In this chapter, we review current immunotherapy and its challenges as well as the latest nanotechnology applications in cancer immunotherapy.

引用

页码：35 / 56

页数：22

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