Chickenpox in varicella IgG positive patients: Experience of a regional paediatric oncology centre

被引：15

作者：

Manley, Sue ^{[1
]}

Mallinson, Harry ^{[2
]}

Caswell, Mark ^{[1
]}

Keenan, Russell ^{[1
]}

Pizer, Barry ^{[1
]}

机构：

[1] RLC NHS Trust Alder Hey, Dept Paediat Oncol, Liverpool L12 2AP, Merseyside, England

[2] Aintree Hosp Fdn NHS Trust, Dept Clin Microbiol, Liverpool, Merseyside, England

来源：

PEDIATRIC BLOOD & CANCER | 2008年 / 51卷 / 04期

关键词：

cancer; chicken pox; child; immunocompromised; leukaemia; varicella; varicella IgG;

D O I：

10.1002/pbc.21521

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aciclovir prophylaxis was previously given to all immunocompromised patients treated by our unit, following contact with varicella zoster. In 2003, we changed practice according to National Guidelines, giving prophylaxis only to patients without serum varicella zoster immunoglobulin G antibody (VZ IgG) at diagnosis of their malignancy. Since then we have seen nine patients with acute lymphoblastic leukaemia (ALL) and VZ IgG positivity at diagnosis of their malignancy develop chickenpox. Our observations question current practice for patients with ALL.

引用

页码：540 / 542

页数：3

共 19 条

[1] Severe complications of chickenpox in hospitalised children in the UK and Ireland [J].

Cameron, J. C. ;

Allan, G. ;

Johnston, F. ;

Finn, A. ;

Heath, P. T. ;

Booy, R. .

ARCHIVES OF DISEASE IN CHILDHOOD, 2007, 92 (12) :1062-1066

[2]

DIAZ PS, 1991, PEDIATRICS, V87, P166

[3]

DOWELL SF, 1993, PEDIATRICS, V92, P223

[4]

FELDMAN S, 1975, PEDIATRICS, V56, P388

[5]

FELDMAN S, 1987, PEDIATRICS, V80, P465

[6]

GERSHON AA, 1986, PEDIATRICS, V78, P757

[7] Recent steroid therapy increases severity of varicella infections in children with acute lymphoblastic leukemia [J].

Hill, G ;

Chauvenet, AR ;

Lovato, J ;

McLean, TW .

PEDIATRICS, 2005, 116 (04) :E525-E529

[8] Clinical relevance of quantitative varicella-zoster virus (VZV) DNA detection in plasma after stem cell transplantation [J].

Kalpoe, J. S. ;

Kroes, A. C. M. ;

Verkerk, S. ;

Claas, E. C. J. ;

Barge, R. M. Y. ;

Beersma, M. F. C. .

BONE MARROW TRANSPLANTATION, 2006, 38 (01) :41-46

[9] Varicella vaccine in non-immune household contacts of children with cancer or leukaemia [J].

Kappagoda, C ;

Shaw, PJ ;

Burgess, MA ;

Botham, SJ ;

Cramer, LD .

JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 1999, 35 (04) :341-345

[10] FATAL VARICELLA AFTER A SINGLE COURSE OF CORTICOSTEROIDS [J].

KASPER, WJ ;

HOWE, PM .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1990, 9 (10) :729-732

← 1 2 →