Methylenetetrahydrofolate reductase gene (C677T and A1298C) polymorphisms and hyperhomocysteinemia as risk factors for Myocardial Infarction

被引：0
|
作者：
Eissa, Adil A. [1 ]
Rasool, Chiman Saleem [2 ]
Mustafa, Majeed Hussein [3 ]
机构：
[1] Univ Duhok, Coll Med, Dept Pathol, Duhok 78, Iraq
[2] Univ Duhok, Coll Nursing, Dept Biol, Duhok 78, Iraq
[3] Univ Duhok, Coll Hlth Sci, Duhok 78, Iraq
来源：
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS | 2019年 / 56卷 / 04期
关键词：
Hyperhomocysteinemia; Kurds; Methylenetetrahydrofolate reductase; Myocardial infarction; UNIVERSAL DEFINITION; DISEASE RISK; MTHFR; HOMOCYSTEINE; DISORDER;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Conflicting data concerning the association between methylenetetrahydrofolate reductase gene MTHFR (C677T and A1298C) polymorphisms with or without hyperhomocysteinemia and myocardial infarction exists and data from developing countries is limited thus, a current study initiated to study whether any association exist between the above polymorphisms and myocardial infarction among Kurdish patients from Duhok province/Iraq. A case-control study was performed in Azadi teaching hospital/Duhok/Iraq and included 75 patients with acute myocardial infarction and 75 age and sex-matched normal controls. All the patients and controls had their methylenetetrahydrofolate reductase gene analyzed for C677T and A1298C polymorphism using polymerase chain reaction/restriction fragment length polymorphism technique as well as their homocysteine level.
引用
收藏
页码：321 / 324
页数：4
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