In search of a better understanding of IgA nephropathy-associated hematuria

被引：12

作者：

Eitner, Frank ^{[1
,2
]}

Floege, Juergen ^{[2
]}

机构：

[1] Bayer Pharma AG, Global Drug Dev, Kidney Dis Res, D-42096 Wuppertal, Germany

[2] Rhein Westfal TH Aachen, Div Nephrol & Clin Immunol, Aachen, Germany

来源：

KIDNEY INTERNATIONAL | 2012年 / 82卷 / 05期

关键词：

FRACTALKINE; EXPRESSION; DISEASE; CX3CR1;

D O I：

10.1038/ki.2012.160

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Although microscopic or episodic macroscopic hematuria is the key clinical manifestation of IgA nephropathy (IgAN), still very little is known about its pathogenesis. Cox et al. studied IgAN patients during episodes of macroscopic hematuria and identified an upregulated expression of the chemokine receptor CX3CR1 in their circulating leukocytes. On the basis of a series of additional experimental approaches, they suggest that CX3CR1 and its ligand fractalkine may contribute to the onset of macroscopic hematuria in IgAN.

引用

页码：513 / 515

页数：3

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