Electrochemically Enabled Dehydrogenative Phosphorothiolation of 2H-Indazoles under Electrolyte-Free Conditions

被引：29

作者：

Ghosh, Payel ^{[1
]}

Hajra, Alakananda ^{[1
]}

机构：

[1] Visva Bharati, Dept Chem, Santini Ketan 731235, W Bengal, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 23期

关键词：

Electrooxidation; Phosphorothiolation; cross dehydrogenative coupling; Electrolyte-free; 2H-indazole; BORONIC ACIDS; FUNCTIONALIZATION; AMINATION; ACCESS;

D O I：

10.1002/adsc.202200932

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We have developed an electrochemical method for phosphorothiolation of 2H-indazoles using S-hydrogen phosphorothioates via cross dehydrogenative coupling reaction under metal-free and electrolyte-free conditions. This protocol is compatible with electron donating groups like -Me, -OMe, halogen and elctron withdrawing groups such as -COOEt, affording respective indazolyl phosphorothioates in 62%-91% yields. Comprehensive mechanistic studies indicate that the reaction proceeds through a radical pathway.

引用

页码：4157 / 4165

页数：9

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