Genetics and Epigenetics of Systemic Lupus Erythematosus
被引:53
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作者:
Costa-Reis, Patricia
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机构:
Childrens Hosp Philadelphia, Abramson Res Ctr 1214, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
Univ Lisbon, Fac Med, P-1699 Lisbon, PortugalChildrens Hosp Philadelphia, Abramson Res Ctr 1214, Philadelphia, PA 19104 USA
Costa-Reis, Patricia
[1
,2
,3
]
Sullivan, Kathleen E.
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机构:
Childrens Hosp Philadelphia, Abramson Res Ctr 1214, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Abramson Res Ctr 1214, Philadelphia, PA 19104 USA
Sullivan, Kathleen E.
[1
,2
]
机构:
[1] Childrens Hosp Philadelphia, Abramson Res Ctr 1214, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
Genetics unquestionably contributes to systemic lupus erythematosus (SLE) predisposition, progression and outcome. Nevertheless, single-gene defects causing lupus-like phenotypes have been infrequently documented. The majority of the identified genetic SLE risk factors are, therefore, common variants, responsible for a small effect on the global risk. Recently, genome wide association studies led to the identification of a growing number of gene variants associated with SLE susceptibility, particular disease phenotypes, and antibody profiles. Further studies addressed the biological effects of these variants. In addition, the role of epigenetics has recently been revealed. These combined efforts contributed to a better understanding of SLE pathogenesis and to the characterization of clinically relevant pathways. In this review, we describe SLE-associated single-gene defects, common variants, and epigenetic changes. We also discuss the limitations of currentmethods and the challenges that we still have to face in order to incorporate genomic and epigenomic data into clinical practice.
机构:
Hosp Sick Children, Div Rheumatol, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Carlomagno, Raffaella
Liao, Fangming
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Hosp Sick Children, Res Inst, Genet & Genome Biol, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Liao, Fangming
Cao, JingJing
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Hosp Sick Children, Res Inst, Genet & Genome Biol, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Cao, JingJing
Gladman, Dafna
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Sick Children, Res Inst, Genet & Genome Biol, Toronto, ON, Canada
Toronto Western Hosp, Krembil Res Inst, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Gladman, Dafna
Klein-Gitelman, Marisa
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机构:
Ann & Robert H Lurie Childrens Hosp Chicago, Dept Pediat, Div Rheumatol, Chicago, IL 60611 USAHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Klein-Gitelman, Marisa
Knight, Andrea
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机构:
Hosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Univ Toronto, Dept Paediat, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Knight, Andrea
Levy, Deborah
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Hosp Sick Children, Div Rheumatol, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Levy, Deborah
Onel, Karen
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机构:
Hosp Special Surg, Pediat Rheumatol, 535 E 70th St, New York, NY 10021 USAHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Onel, Karen
Paterson, Andrew
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h-index: 0
机构:
Hosp Sick Children, Res Inst, Genet & Genome Biol, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Paterson, Andrew
Peschken, Christine
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h-index: 0
机构:
Univ Manitoba, Dept Med, Winnipeg, MB, Canada
Univ Manitoba, Dept Community Hlth Sci, Winnipeg, MB, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Peschken, Christine
Pope, Janet
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Univ Western Ontario, Dept Med, St Josephs Hlth Ctr, London, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Pope, Janet
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机构:
Touma, Zahi
Urowitz, Murray
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Univ Hlth Network, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Urowitz, Murray
Webber, Declan
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机构:
Hosp Sick Children, Div Rheumatol, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Webber, Declan
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Wither, Joan
Silverman, Earl D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Dept Paediat, Toronto, ON, Canada
Hosp Sick Children, Div Rheumatol, Translat Med, Res Inst, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Silverman, Earl D.
Hiraki, Linda
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机构:
Univ Toronto, Dept Paediat, Toronto, ON, Canada
Hosp Sick Children, Child Hlth Evaluat Sci, Res Inst, Div Rheumatol, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
机构:
Cent South Univ, Xiangya Hosp 2, Dept Dermatol, Hunan Key Lab Med Epigenom, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Dept Dermatol, Hunan Key Lab Med Epigenom, Changsha, Hunan, Peoples R China
Wu, Haijing
Chang, Christopher
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机构:
Joe DiMaggio Childrens Hosp, Div Pediat Immunol & Allergy, Hollywood, FL 33021 USA
Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USACent South Univ, Xiangya Hosp 2, Dept Dermatol, Hunan Key Lab Med Epigenom, Changsha, Hunan, Peoples R China
Chang, Christopher
Lu, Qianjin
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机构:
Cent South Univ, Xiangya Hosp 2, Dept Dermatol, Hunan Key Lab Med Epigenom, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Dept Dermatol, Hunan Key Lab Med Epigenom, Changsha, Hunan, Peoples R China
Lu, Qianjin
EPIGENETICS IN ALLERGY AND AUTOIMMUNITY,
2020,
1253
: 185
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207
机构:
Cent S Univ, Xiangya Hosp 2, Dept Dermatol, Changsha 410011, Hunan, Peoples R China
Cent S Univ, Xiangya Hosp 2, Epigenet Res Ctr, Changsha 410011, Hunan, Peoples R ChinaCent S Univ, Xiangya Hosp 2, Dept Dermatol, Changsha 410011, Hunan, Peoples R China
Guo, Yu
Sawalha, Amr H.
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机构:
Univ Michigan, Dept Internal Med, Div Rheumatol, Ann Arbor, MI 48109 USACent S Univ, Xiangya Hosp 2, Dept Dermatol, Changsha 410011, Hunan, Peoples R China
Sawalha, Amr H.
Lu, Qianjin
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机构:
Cent S Univ, Xiangya Hosp 2, Dept Dermatol, Changsha 410011, Hunan, Peoples R China
Cent S Univ, Xiangya Hosp 2, Epigenet Res Ctr, Changsha 410011, Hunan, Peoples R ChinaCent S Univ, Xiangya Hosp 2, Dept Dermatol, Changsha 410011, Hunan, Peoples R China
机构:
Hosp Sick Children, Div Rheumatol, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Webber, Declan
Cao, Jingjing
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机构:
Hosp Sick Children, Res Inst, Genet & Genome Biol, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Cao, Jingjing
Dominguez, Daniela
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Hosp Sick Children, Div Rheumatol, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Dominguez, Daniela
Gladman, Dafna D.
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机构:
Univ Hlth Network, Toronto Western Hosp, Schroeder Arthrit Inst, Krembil Res Inst, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Gladman, Dafna D.
Knight, Andrea
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机构:
Hosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Univ Toronto, Dept Paediat, Toronto, ON, Canada
Hosp Sick Children, Res Inst, Neurosci & Mental Hlth, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Knight, Andrea
Levy, Deborah M.
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机构:
Hosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Univ Toronto, Dept Paediat, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Levy, Deborah M.
Liao, Fangming
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机构:
Hosp Sick Children, Div Rheumatol, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Liao, Fangming
Ng, Lawrence
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Hosp Sick Children, Div Rheumatol, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Ng, Lawrence
Paterson, Andrew D.
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Hosp Sick Children, Res Inst, Genet & Genome Biol, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Paterson, Andrew D.
Touma, Zahi
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h-index: 0
机构:
Univ Hlth Network, Toronto Western Hosp, Schroeder Arthrit Inst, Krembil Res Inst, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Touma, Zahi
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Wither, Joan
Urowitz, Murray
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hlth Network, Toronto Western Hosp, Schroeder Arthrit Inst, Krembil Res Inst, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Urowitz, Murray
Silverman, Earl D.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Univ Toronto, Dept Paediat, Toronto, ON, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Silverman, Earl D.
Hiraki, Linda T.
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h-index: 0
机构:
Hosp Sick Children, Div Rheumatol, Toronto, ON, Canada
Hosp Sick Children, Res Inst, Genet & Genome Biol, Toronto, ON, Canada
Univ Toronto, Dept Paediat, Toronto, ON, Canada
Hosp Sick Children, PGCRL, 686 Bay St, Toronto, ON M5G 0A4, CanadaHosp Sick Children, Div Rheumatol, Toronto, ON, Canada