An Amperometric Sensor for Low Level Detection of Antidepressant Drug Carbamazepine Based on Graphene Oxide-g-C3N4 Composite Film Modified Electrode

被引：37
作者：
Balasubramanian, Paramasivam [1 ]
Balamurugan, T. S. T. [1 ,2 ]
Chen, Shen-Ming [1 ]
Chen, Tse-Wei [1 ]
Ali, M. Ajmal [3 ]
Al-Hemaid, Fahad M. A. [3 ]
Elshikh, M. S. [3 ]
机构：
[1] Natl Taipei Univ Technol, Dept Chem Engn & Biotechnol, Taipei 106, Taiwan
[2] Natl Taipei Univ Technol, Inst Biochem & Biomed Engn, Taipei 106, Taiwan
[3] King Saud Univ, Dept Bot & Microbiol, Riyadh 11451, Saudi Arabia
来源：
JOURNAL OF THE ELECTROCHEMICAL SOCIETY | 2018年 / 165卷 / 03期
关键词：
TRICYCLIC ANTICONVULSANTS; ELECTROCHEMICAL SENSOR; ANTIEPILEPTIC DRUGS; CARBON NITRIDE; PHARMACEUTICALS; G-C3N4; NANOPARTICLES; REDUCTION; OXIDATION; HYBRID;
D O I：
10.1149/2.0071805jes
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
Present strategy reports a simple electrochemical sensor for highly sensitive, selective detection of carbamazepine based on the graphene oxide and graphitic carbon nitride composite film modified electrode. The GO/g-C3N4 composite film exhibit incredible electrocatalytic activity in terms of minimized over potential (0.1 V) associated with enhanced anodic current with 4 fold higher than that of control electrode. In addition, the developed sensor yields a very lower detection limit (10.5 nM) with good sensitivity (1.727 mu A mu M-1 cm(-2)). Furthermore, the developed assay was employed in the determination of CBZ in human urine samples and pharmaceutical samples. Analytical results are reliable, suggested that the proposed sensor can be used for the determination of CBZ in biological and pharmaceutical samples. (C) 2018 The Electrochemical Society.
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页码：B160 / B166
页数：7
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